Trp53 loss drives the neoplastic transformation of Pik3caH1047R-induced vascular malformation in a mouse model

Miaolu Tang; Jessica Sallavanti; Matthew Lanza; Danielle Covington; Wei Li

doi:10.1371/journal.pone.0348285

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Peer-reviewed

Research Article

Trp53 loss drives the neoplastic transformation of Pik3ca^H1047R-induced vascular malformation in a mouse model

Miaolu Tang,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Division of Hematology and Oncology, Department of Pediatrics, Penn State College of Medicine, Hershey, Pennsylvania, United States of America

https://orcid.org/0000-0001-6441-1851

⨯
Jessica Sallavanti,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Division of Hematology and Oncology, Department of Pediatrics, Penn State College of Medicine, Hershey, Pennsylvania, United States of America
⨯
Matthew Lanza,

Roles Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

Affiliation Department of Comparative Medicine, Penn State College of Medicine, Hershey, Pennsylvania, United States of America
⨯
Danielle Covington,

Roles Formal analysis, Investigation, Visualization, Writing – original draft, Writing – review & editing

Current Address: Laboratory Animal Sciences & Governance, GSK, Collegeville, PA, United States of America

Affiliation Department of Comparative Medicine, Penn State College of Medicine, Hershey, Pennsylvania, United States of America
⨯
Wei Li

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: weili@pennstatehealth.psu.edu

Affiliations Division of Hematology and Oncology, Department of Pediatrics, Penn State College of Medicine, Hershey, Pennsylvania, United States of America, Department of Cell and Biological Systems, Penn State College of Medicine, Hershey, Pennsylvania, United States of America, Penn State Cancer Institute, Penn State College of Medicine, Hershey, Pennsylvania, United States of America

https://orcid.org/0000-0001-5696-4309

⨯

Trp53 loss drives the neoplastic transformation of Pik3ca^H1047R-induced vascular malformation in a mouse model

Miaolu Tang,
Jessica Sallavanti,
Matthew Lanza,
Danielle Covington,
Wei Li

Published: May 4, 2026
https://doi.org/10.1371/journal.pone.0348285

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