Ulinastatin attenuates capillary leakage and suppresses FoxO1-dependent angiopoietin-2 in sepsis-associated acute lung injury via PI3K pathway

• Yating Lv ,

  Roles Conceptualization, Data curation, Formal analysis, Methodology, Writing – original draft, Writing – review & editing

  ¶☯ Both authors contributed equally to this work.

  Affiliation Department of Critical Care Medicine of the Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou City, Gansu Province, People’s Republic of China

  https://orcid.org/0009-0009-1084-8359

  ⨯
• Yanfei Meng ,

  Roles Validation, Visualization, Writing – original draft

  ¶☯ Both authors contributed equally to this work.

  Affiliation Department of Critical Care Medicine of the Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou City, Gansu Province, People’s Republic of China

  ⨯
• Haiying Rui,

  Roles Conceptualization, Software, Supervision, Writing – original draft

  Affiliation Department of Critical Care Medicine of the Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou City, Gansu Province, People’s Republic of China

  ⨯
• Tongqin Li,

  Roles Data curation, Formal analysis

  Affiliation Department of Critical Care Medicine of the Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou City, Gansu Province, People’s Republic of China

  ⨯
• Jing Zhang,

  Roles Investigation, Validation

  Affiliation Department of Critical Care Medicine of the Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou City, Gansu Province, People’s Republic of China

  ⨯
• Jie Liu,

  Roles Formal analysis

  Affiliation Department of Critical Care Medicine of the Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou City, Gansu Province, People’s Republic of China

  ⨯
• Xin Ma,

  Roles Investigation, Methodology

  Affiliation Department of Critical Care Medicine of the Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou City, Gansu Province, People’s Republic of China

  ⨯
• Jiaqi Wang,

  Roles Formal analysis, Investigation

  Affiliation Department of Critical Care Medicine of the Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou City, Gansu Province, People’s Republic of China

  ⨯
• Yamin Yuan,

  Roles Conceptualization

  Affiliation Department of Critical Care Medicine of the Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou City, Gansu Province, People’s Republic of China

  ⨯
• Yujing Jiang,

  Roles Software

  Affiliation Department of Critical Care Medicine of the Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou City, Gansu Province, People’s Republic of China

  ⨯
• Xiaoxi Yan,

  Roles Project administration

  Affiliation Department of Critical Care Medicine of the Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou City, Gansu Province, People’s Republic of China

  ⨯
• Miaobo Li,

  Roles Validation

  Affiliation Department of Critical Care Medicine of the Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou City, Gansu Province, People’s Republic of China

  ⨯
• Xiaorong Dong,

  Roles Visualization

  Affiliation Department of Critical Care Medicine of the Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou City, Gansu Province, People’s Republic of China

  ⨯
• Bei Zhang,

  Roles Resources

  Affiliation Department of Critical Care Medicine of the Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou City, Gansu Province, People’s Republic of China

  ⨯
• Li Ma

  Roles Funding acquisition

  * E-mail: ery_mali@lzu.edu.cn

  Affiliation Department of Critical Care Medicine of the Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou City, Gansu Province, People’s Republic of China

  https://orcid.org/0000-0002-9728-7313

  ⨯