Combinatorial drug repurposing of Valproic acid and Zebularine regulates Krüppel-like factor 4 and β-catenin expression in colon cancer cells

• Jeyalakshmi Kandhavelu,

  Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Oncology Division, Department of Internal Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa

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• Kumar Subramanian,

  Roles Data curation, Formal analysis, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Oncology Division, Department of Internal Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa

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• Natanya Moodley,

  Roles Data curation, Formal analysis, Methodology, Visualization

  Affiliation Oncology Division, Department of Internal Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa

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• Kasim S. Abass,

  Roles Resources, Software, Visualization, Writing – review & editing

  Affiliation College of Veterinary Medicine, Department of Physiology,‌‌ Biochemistry, and Pharmacology, University of Kirkuk, Kirkuk, Iraq

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• Chandrabose Sureka,

  Roles Software, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Department of Basic Medical Sciences, College of Medicine, Prince Sattam Bin Abdulaziz University, Al-Kharj, Saudi Arabia

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• Meenakshisundaram Kandhavelu ,

  Roles Funding acquisition, Investigation, Project administration, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: meenakshisundaram.kandhavelu@tuni.fi (MK); Clement.Penny@wits.ac.za (CP)

  Affiliation Molecular Signaling Group, Faculty of Medicine and Health Technology, BioMediTech, ‌‌Tampere University and Tays Cancer Center, Tampere, Finland

  https://orcid.org/0000-0002-4986-055X

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• Paul Ruff,

  Roles Funding acquisition, Investigation, Project administration, Supervision, Writing – original draft, Writing – review & editing

  Affiliation Oncology Division, Department of Internal Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa

  https://orcid.org/0000-0003-1055-1730

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• Clement Penny

  Roles Conceptualization, Funding acquisition, Investigation, Project administration, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: meenakshisundaram.kandhavelu@tuni.fi (MK); Clement.Penny@wits.ac.za (CP)

  Affiliation Oncology Division, Department of Internal Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa

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