Perianal lidocaine application during unsedated colonoscopy: A double-blind randomized controlled trial

Jiankun Wang; Yuwen Tao; Rui Wu; Lili Zhao; Li Liu; Zhining Fan; Wentao Fan

doi:10.1371/journal.pone.0348062

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Open Access

Peer-reviewed

Research Article

Perianal lidocaine application during unsedated colonoscopy: A double-blind randomized controlled trial

Jiankun Wang ,

Contributed equally to this work with: Jiankun Wang, Yuwen Tao

Roles Conceptualization, Data curation, Formal analysis

Affiliation Department of Geriatric Gastroenterology, the First Affiliated Hospital with Nanjing Medical University & Jiangsu Province Hospital, Nanjing, China

https://orcid.org/0009-0006-9956-8377

⨯
Yuwen Tao ,

Contributed equally to this work with: Jiankun Wang, Yuwen Tao

Roles Writing – original draft

Affiliation Department of Geriatric Gastroenterology, the First Affiliated Hospital with Nanjing Medical University & Jiangsu Province Hospital, Nanjing, China
⨯
Rui Wu,

Roles Project administration

Affiliation Department of Geriatric Gastroenterology, the First Affiliated Hospital with Nanjing Medical University & Jiangsu Province Hospital, Nanjing, China
⨯
Lili Zhao,

Roles Supervision

Affiliation Department of Geriatric Gastroenterology, the First Affiliated Hospital with Nanjing Medical University & Jiangsu Province Hospital, Nanjing, China
⨯
Li Liu,

Roles Investigation

Affiliation Department of Geriatric Gastroenterology, the First Affiliated Hospital with Nanjing Medical University & Jiangsu Province Hospital, Nanjing, China
⨯
Zhining Fan ,

Roles Validation

* E-mail: fanzhining@njmu.edu.cn (ZF); drwentao@126.com (WF)

Affiliation Department of Geriatric Gastroenterology, the First Affiliated Hospital with Nanjing Medical University & Jiangsu Province Hospital, Nanjing, China
⨯
Wentao Fan

Roles Software, Writing – original draft, Writing – review & editing

* E-mail: fanzhining@njmu.edu.cn (ZF); drwentao@126.com (WF)

Affiliations Department of Geriatric Gastroenterology, the First Affiliated Hospital with Nanjing Medical University & Jiangsu Province Hospital, Nanjing, China, Gastroenterology Department, the Fourth Affiliated Hospital of Nanjing Medical University, Nanjing, China

https://orcid.org/0009-0007-0178-5195

⨯

Perianal lidocaine application during unsedated colonoscopy: A double-blind randomized controlled trial

Jiankun Wang,
Yuwen Tao,
Rui Wu,
Lili Zhao,
Li Liu,
Zhining Fan,
Wentao Fan

Published: April 30, 2026
https://doi.org/10.1371/journal.pone.0348062

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