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Open Access

Efficacy and safety of the ayurvedic formulation ‘Trikatu’ as an add-on to standard care in dyslipidemia: Study protocol for a randomized, double-blind, placebo-controlled trial evaluating lipid parameters, and gut microbiota

Shruti Khanduri,

Roles Conceptualization, Funding acquisition, Writing – original draft

Affiliation Department of Ayurveda, Central Council for Research in Ayurvedic Sciences, Ministry of Ayush, New Delhi, India
⨯
Sophia Jameela ,

Roles Conceptualization, Funding acquisition, Writing – original draft

* E-mail: drsophia9754@gmail.com

Affiliation Department of Ayurveda, Central Council for Research in Ayurvedic Sciences, Ministry of Ayush, New Delhi, India

https://orcid.org/0000-0001-6685-3610

⨯
Suchanda Sahu,

Roles Conceptualization, Investigation

Affiliation Department of Biochemistry, All India Institute of Medical Sciences, Bhubaneswar, India
⨯
Sujata Devi,

Roles Investigation, Methodology

Affiliation Department of General Medicine, All India Institute of Medical Sciences, Bhubaneswar, India
⨯
Bhogavalli Chandra Sekhara Rao,

Roles Conceptualization, Project administration

Affiliation Department of Ayurveda, Central Council for Research in Ayurvedic Sciences, Ministry of Ayush, New Delhi, India
⨯
Kshirod Ratha,

Roles Formal analysis, Writing – review & editing

Affiliation Department of Ayurveda, Central Ayurveda Research Institute, Bhubaneswar, India
⨯
Richa Singhal,

Roles Data curation, Formal analysis

Affiliation Scientist C, Indian Council for Medical Research-National Institute of Malaria Research, New Delhi, India
⨯
Latika Kaushik,

Roles Writing – review & editing

Affiliation Department of Ayurveda, Central Council for Research in Ayurvedic Sciences, Ministry of Ayush, New Delhi, India
⨯
Narayanam Srikanth,

Roles Conceptualization, Project administration

Affiliation Deputy Director General, Central Council for Research in Ayurvedic Sciences, Ministry of Ayush, New Delhi, India
⨯
Rabinarayan Acharya

Roles Project administration

Affiliation Former Director General, Central Council for Research in Ayurvedic Sciences, Ministry of Ayush, New Delhi, India
⨯

Efficacy and safety of the ayurvedic formulation ‘Trikatu’ as an add-on to standard care in dyslipidemia: Study protocol for a randomized, double-blind, placebo-controlled trial evaluating lipid parameters, and gut microbiota

Shruti Khanduri,
Sophia Jameela,
Suchanda Sahu,
Sujata Devi,
Bhogavalli Chandra Sekhara Rao,
Kshirod Ratha,
Richa Singhal,
Latika Kaushik,
Narayanam Srikanth,
Rabinarayan Acharya

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Published: May 11, 2026
https://doi.org/10.1371/journal.pone.0348058

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Statins
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Cardiovascular disease risk
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Dyslipidemia
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Lipids
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Cholesterol
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Cardiovascular therapy
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Inflammation
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Gut bacteria
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