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Open Access
Peer-reviewed
Research Article
Inhibition of neutrophil infiltration and NETs formation ameliorates neuropsychiatric and renal dysfunction in MRL/lpr mice with lupus
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Yiyao Deng ,
Contributed equally to this work with: Yiyao Deng, Yu Shang
Roles Conceptualization, Writing – original draft, Writing – review & editing
Affiliations Department of Nephrology, Guizhou Provincial People’s Hospital, Guiyang, Guizhou, China, NHC Key Laboratory of Pulmonary Immunological Disease, Guizhou Provincial People’s Hospital, Guiyang, Guizhou, China, Department of Nephrology, The First Medical Centre, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Centre for Kidney Diseases, Beijing Key Laboratory of Kidney Diseases, Beijing, China
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Yu Shang ,
Contributed equally to this work with: Yiyao Deng, Yu Shang
Roles Data curation, Writing – original draft
Affiliation Guizhou University of Traditional Chinese Medicine, Guiyang, Guizhou, China
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Yongqiang Zhang,
Roles Methodology, Validation
Affiliations Department of Nephrology, Guizhou Provincial People’s Hospital, Guiyang, Guizhou, China, NHC Key Laboratory of Pulmonary Immunological Disease, Guizhou Provincial People’s Hospital, Guiyang, Guizhou, China
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Delun Li,
Roles Methodology, Validation
Affiliation The Second Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, China
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Yongle Xiong,
Roles Methodology, Validation
Affiliation Anesthesiology department, Guizhou Provincial People’s Hospital, Guiyang, Guizhou, China
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Yan Shen,
Roles Methodology, Resources
Affiliations Department of Nephrology, Guizhou Provincial People’s Hospital, Guiyang, Guizhou, China, NHC Key Laboratory of Pulmonary Immunological Disease, Guizhou Provincial People’s Hospital, Guiyang, Guizhou, China
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Lu Liu,
Roles Funding acquisition, Investigation, Methodology
Affiliations Department of Nephrology, Guizhou Provincial People’s Hospital, Guiyang, Guizhou, China, NHC Key Laboratory of Pulmonary Immunological Disease, Guizhou Provincial People’s Hospital, Guiyang, Guizhou, China
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Yan Ran,
Roles Funding acquisition, Investigation, Methodology
Affiliations Department of Nephrology, Guizhou Provincial People’s Hospital, Guiyang, Guizhou, China, NHC Key Laboratory of Pulmonary Immunological Disease, Guizhou Provincial People’s Hospital, Guiyang, Guizhou, China
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Pinghong He,
Roles Investigation, Methodology
Affiliations Department of Nephrology, Guizhou Provincial People’s Hospital, Guiyang, Guizhou, China, NHC Key Laboratory of Pulmonary Immunological Disease, Guizhou Provincial People’s Hospital, Guiyang, Guizhou, China
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Shuang Chen,
Roles Investigation, Methodology, Validation
Affiliations Department of Nephrology, Guizhou Provincial People’s Hospital, Guiyang, Guizhou, China, NHC Key Laboratory of Pulmonary Immunological Disease, Guizhou Provincial People’s Hospital, Guiyang, Guizhou, China
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Libo Wu,
Roles Methodology, Validation
Affiliations Department of Nephrology, Guizhou Provincial People’s Hospital, Guiyang, Guizhou, China, NHC Key Laboratory of Pulmonary Immunological Disease, Guizhou Provincial People’s Hospital, Guiyang, Guizhou, China
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Shanshan Hu,
Roles Investigation, Methodology
Affiliations Department of Nephrology, Guizhou Provincial People’s Hospital, Guiyang, Guizhou, China, NHC Key Laboratory of Pulmonary Immunological Disease, Guizhou Provincial People’s Hospital, Guiyang, Guizhou, China
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Lulu Liu,
Roles Investigation, Methodology
Affiliations Department of Nephrology, Guizhou Provincial People’s Hospital, Guiyang, Guizhou, China, NHC Key Laboratory of Pulmonary Immunological Disease, Guizhou Provincial People’s Hospital, Guiyang, Guizhou, China
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Zhi Yang,
Roles Investigation, Methodology
Affiliation Guizhou University of Traditional Chinese Medicine, Guiyang, Guizhou, China
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Yan Zha ,
Roles Investigation, Methodology
* E-mail: shenyan09@163.com (YZ); yuanjinger12@163.com (JY)
Affiliations Department of Nephrology, Guizhou Provincial People’s Hospital, Guiyang, Guizhou, China, NHC Key Laboratory of Pulmonary Immunological Disease, Guizhou Provincial People’s Hospital, Guiyang, Guizhou, China
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Jing Yuan
Roles Investigation, Methodology, Writing – original draft, Writing – review & editing
* E-mail: shenyan09@163.com (YZ); yuanjinger12@163.com (JY)
Affiliations Department of Nephrology, Guizhou Provincial People’s Hospital, Guiyang, Guizhou, China, NHC Key Laboratory of Pulmonary Immunological Disease, Guizhou Provincial People’s Hospital, Guiyang, Guizhou, China
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Inhibition of neutrophil infiltration and NETs formation ameliorates neuropsychiatric and renal dysfunction in MRL/lpr mice with lupus
- Yiyao Deng,
- Yu Shang,
- Yongqiang Zhang,
- Delun Li,
- Yongle Xiong,
- Yan Shen,
- Lu Liu,
- Yan Ran,
- Pinghong He,
- Shuang Chen
- Published: May 22, 2026
- https://doi.org/10.1371/journal.pone.0348011