Calcitriol attenuates diethylnitrosamine-induced hepatic fibrosis in rats by reducing oxidative stress and fibrogenic mediators

Komsan Arramrak; Namthip Witayavanitkul; Maneerat Chayanupatkul; Natcha Wanpiyarat; Prasong Siriviriyakul; Duangporn Werawatganon

doi:10.1371/journal.pone.0347908

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Open Access

Peer-reviewed

Research Article

Calcitriol attenuates diethylnitrosamine-induced hepatic fibrosis in rats by reducing oxidative stress and fibrogenic mediators

Komsan Arramrak,

Roles Data curation, Formal analysis, Investigation, Methodology, Writing – original draft

Affiliation Center of Excellence in Alternative and Complementary Medicine for Gastrointestinal and Liver Diseases, Department of Physiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand

https://orcid.org/0009-0000-7514-9035

⨯
Namthip Witayavanitkul ,

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Writing – review & editing

* E-mail: namthip.wi@chula.ac.th

Affiliation Center of Excellence in Alternative and Complementary Medicine for Gastrointestinal and Liver Diseases, Department of Physiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand

https://orcid.org/0000-0003-3588-3766

⨯
Maneerat Chayanupatkul,

Roles Formal analysis, Methodology, Writing – review & editing

Affiliation Center of Excellence in Alternative and Complementary Medicine for Gastrointestinal and Liver Diseases, Department of Physiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
⨯
Natcha Wanpiyarat,

Roles Formal analysis, Writing – review & editing

Affiliation Department of Pathology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
⨯
Prasong Siriviriyakul,

Roles Conceptualization, Supervision, Writing – review & editing

Affiliation Center of Excellence in Alternative and Complementary Medicine for Gastrointestinal and Liver Diseases, Department of Physiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
⨯
Duangporn Werawatganon

Roles Conceptualization, Formal analysis, Methodology, Supervision, Writing – review & editing

Affiliation Center of Excellence in Alternative and Complementary Medicine for Gastrointestinal and Liver Diseases, Department of Physiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
⨯

Calcitriol attenuates diethylnitrosamine-induced hepatic fibrosis in rats by reducing oxidative stress and fibrogenic mediators

Komsan Arramrak,
Namthip Witayavanitkul,
Maneerat Chayanupatkul,
Natcha Wanpiyarat,
Prasong Siriviriyakul,
Duangporn Werawatganon

Published: May 6, 2026
https://doi.org/10.1371/journal.pone.0347908

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