Extensive intraoperative peritoneal lavage (EIPL) for gastric cancer with positive peritoneal lavage and/or stamp cytology: An exploratory phase II study

Gen Tsujio; Masakazu Yashiro; Yuichiro Miki; Kohei Matsuoka; Koji Maruo; Mami Yoshii; Tatsuro Tamura; Katsunobu Sakurai; Takahiro Toyokawa; Naoshi Kubo; Shigeru Lee; Tomohisa Okuno; Kishu Kitayama; Go Masuda; Masaichi Ohira; Kiyoshi Maeda

doi:10.1371/journal.pone.0347742

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Open Access

Peer-reviewed

Research Article

Extensive intraoperative peritoneal lavage (EIPL) for gastric cancer with positive peritoneal lavage and/or stamp cytology: An exploratory phase II study

Gen Tsujio,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft

Affiliations Department of Gastroenterological Surgery, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan, Molecular Oncology and Therapeutics, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan, Cancer Center for Translational Research, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan
⨯
Masakazu Yashiro ,

Roles Supervision, Writing – review & editing

* E-mail: i21496f@omu.ac.jp

Affiliations Department of Gastroenterological Surgery, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan, Molecular Oncology and Therapeutics, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan, Cancer Center for Translational Research, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan

https://orcid.org/0000-0001-5743-7228

⨯
Yuichiro Miki,

Roles Validation, Writing – review & editing

Affiliations Department of Gastroenterological Surgery, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan, Molecular Oncology and Therapeutics, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan
⨯
Kohei Matsuoka,

Roles Writing – review & editing

Affiliation Department of Gastroenterological Surgery, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan
⨯
Koji Maruo,

Roles Investigation

Affiliations Department of Gastroenterological Surgery, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan, Molecular Oncology and Therapeutics, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan, Cancer Center for Translational Research, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan
⨯
Mami Yoshii,

Roles Investigation

Affiliation Department of Gastroenterological Surgery, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan
⨯
Tatsuro Tamura,

Roles Investigation

Affiliation Department of Gastroenterological Surgery, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan
⨯
Katsunobu Sakurai,

Roles Investigation

Affiliation Department of Gastroenterological Surgery, Osaka City General Hospital, Osaka, Japan
⨯
Takahiro Toyokawa,

Roles Investigation

Affiliation Department of Gastroenterological Surgery, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan
⨯
Naoshi Kubo,

Roles Investigation

Affiliation Department of Gastroenterological Surgery, Osaka City General Hospital, Osaka, Japan
⨯
Shigeru Lee,

Roles Investigation

Affiliation Department of Gastroenterological Surgery, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan
⨯
Tomohisa Okuno,

Roles Investigation

Affiliation Department of Gastroenterological Surgery, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan
⨯
Kishu Kitayama,

Roles Investigation

Affiliation Department of Gastroenterological Surgery, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan
⨯
Go Masuda,

Roles Investigation

Affiliation Department of Gastroenterological Surgery, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan
⨯
Masaichi Ohira,

Roles Supervision

Affiliation Department of Gastroenterological Surgery, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan
⨯
[ ... ],
Kiyoshi Maeda

Roles Supervision

Affiliation Department of Gastroenterological Surgery, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan
⨯
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Extensive intraoperative peritoneal lavage (EIPL) for gastric cancer with positive peritoneal lavage and/or stamp cytology: An exploratory phase II study

Gen Tsujio,
Masakazu Yashiro,
Yuichiro Miki,
Kohei Matsuoka,
Koji Maruo,
Mami Yoshii,
Tatsuro Tamura,
Katsunobu Sakurai,
Takahiro Toyokawa,
Naoshi Kubo

Published: April 17, 2026
https://doi.org/10.1371/journal.pone.0347742

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Gastric cancer
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Cytology
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Metastasis
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Surgical and invasive medical procedures
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Gastrectomy
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Cancer risk factors
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Peritoneal lavage
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