Sodium nitrite promotes atherosclerosis via IL-1β: Network toxicology and machine learning insights

HaoBo Yang; YunFeng Yu; YongHui Zhang; YaNan Bai; YaRu Shi; WeiXiong Jian

doi:10.1371/journal.pone.0347642

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Open Access

Peer-reviewed

Research Article

Sodium nitrite promotes atherosclerosis via IL-1β: Network toxicology and machine learning insights

HaoBo Yang,

Roles Investigation, Resources, Visualization, Writing – original draft

Affiliations Hunan Provincial Key Laboratory of TCM Diagnostics, Institute of National Key Discipline in TCM Diagnostics, Changsha, Hunan, China, Hunan University of Chinese Medicine, Changsha, Hunan, China

https://orcid.org/0009-0001-0406-5376

⨯
YunFeng Yu,

Roles Data curation, Writing – review & editing

Affiliations Hunan Provincial Key Laboratory of TCM Diagnostics, Institute of National Key Discipline in TCM Diagnostics, Changsha, Hunan, China, Hunan University of Chinese Medicine, Changsha, Hunan, China
⨯
YongHui Zhang,

Roles Investigation, Writing – review & editing

Affiliations Hunan Provincial Key Laboratory of TCM Diagnostics, Institute of National Key Discipline in TCM Diagnostics, Changsha, Hunan, China, Hunan University of Chinese Medicine, Changsha, Hunan, China
⨯
YaNan Bai,

Roles Conceptualization, Investigation

Affiliations Hunan Provincial Key Laboratory of TCM Diagnostics, Institute of National Key Discipline in TCM Diagnostics, Changsha, Hunan, China, Hunan University of Chinese Medicine, Changsha, Hunan, China
⨯
YaRu Shi,

Roles Investigation, Writing – review & editing

Affiliations Hunan Provincial Key Laboratory of TCM Diagnostics, Institute of National Key Discipline in TCM Diagnostics, Changsha, Hunan, China, Hunan University of Chinese Medicine, Changsha, Hunan, China
⨯
WeiXiong Jian

Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing

* E-mail: daxiong20001977@163.com

Affiliations Hunan Provincial Key Laboratory of TCM Diagnostics, Institute of National Key Discipline in TCM Diagnostics, Changsha, Hunan, China, Hunan University of Chinese Medicine, Changsha, Hunan, China
⨯

Sodium nitrite promotes atherosclerosis via IL-1β: Network toxicology and machine learning insights

HaoBo Yang,
YunFeng Yu,
YongHui Zhang,
YaNan Bai,
YaRu Shi,
WeiXiong Jian

Published: May 5, 2026
https://doi.org/10.1371/journal.pone.0347642

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