Genomic and structural analysis of the endocannabinoid system in Moroccans: A novel CNR1 variant (V392A) impairs CB1 receptor stability

• Hanane Abbou ,

  Roles Conceptualization, Formal analysis, Methodology, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: habbou@um6ss.ma, hanane.abbou95@gmail.com

  Affiliations Laboratory of Drug Sciences (LRSM), Mohammed VI Faculty of Medicine, Casablanca, Mohammed VI University of Sciences and Health (UM6SS), Casablanca, Morocco, Mohammed VI Center for Research and Innovation (CM6RI), Casablanca, Morocco

  https://orcid.org/0009-0002-1793-4638

  ⨯
• Rihab Festali,

  Roles Methodology, Writing – original draft, Writing – review & editing

  Affiliations Mohammed VI Center for Research and Innovation (CM6RI), Casablanca, Morocco, Research Laboratory of Microbiology, Infectious Diseases, Allergology and Pathogen Surveillance (LARMIAS), Mohammed VI Faculty of Medicine, Mohammed VI University of Sciences and Health (UM6SS), Casablanca, Morocco

  ⨯
• Mohammed Walid Chemao-Elfihri,

  Roles Writing – original draft, Writing – review & editing, Methodology

  Affiliations Mohammed VI Center for Research and Innovation (CM6RI), Casablanca, Morocco, Mohammed VI University of Sciences and Health (UM6SS), Casablanca, Morocco

  ⨯
• Mohammed Hakmi,

  Roles Writing – review & editing, Data curation

  Affiliations Mohammed VI Center for Research and Innovation (CM6RI), Casablanca, Morocco, Mohammed VI University of Sciences and Health (UM6SS), Casablanca, Morocco

  ⨯
• Souad Kartti,

  Roles Writing – review & editing, Data curation

  Affiliations Mohammed VI Center for Research and Innovation (CM6RI), Casablanca, Morocco, Mohammed VI University of Sciences and Health (UM6SS), Casablanca, Morocco

  ⨯
• Saber Boutayeb,

  Roles Writing – review & editing

  Affiliations Mohammed VI Center for Research and Innovation (CM6RI), Casablanca, Morocco, Mohammed VI University of Sciences and Health (UM6SS), Casablanca, Morocco

  ⨯
• Lahcen Belyamani,

  Roles Resources

  Affiliations Mohammed VI Center for Research and Innovation (CM6RI), Casablanca, Morocco, Mohammed VI University of Sciences and Health (UM6SS), Casablanca, Morocco

  ⨯
• Rachid Eljaoudi

  Roles Validation, Writing – review & editing, Supervision

  Affiliations Mohammed VI Center for Research and Innovation (CM6RI), Casablanca, Morocco, Biotechnology lab (MedBiotech), Bioinova Research Center, Medical and Pharmacy School, Mohammed V University, Rabat, Morocco

  ⨯