Deciphering the molecular network of Trichostatin A in regulating Alzheimer’s disease screening of core genes and mechanistic investigation based on multidimensional bioinformatics and molecular simulation

Changze Ou; Binbin Chen; Jun Deng; Huajun Long

doi:10.1371/journal.pone.0347532

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Open Access

Peer-reviewed

Research Article

Deciphering the molecular network of Trichostatin A in regulating Alzheimer’s disease screening of core genes and mechanistic investigation based on multidimensional bioinformatics and molecular simulation

Changze Ou ,

Contributed equally to this work with: Changze Ou, Binbin Chen

Roles Conceptualization, Data curation, Formal analysis, Writing – original draft, Writing – review & editing

Affiliations Graduate School, Hunan University of Chinese Medicine, Changsha, Hunan, China, Department of Emergency, Hunan Provincial Hospital of Integrated Traditional Chinese and Western Medicine (Affiliated Hospital of Hunan Academy of Traditional Chinese Medicine), Changsha, Hunan, China
⨯
Binbin Chen ,

Contributed equally to this work with: Changze Ou, Binbin Chen

Roles Conceptualization, Data curation, Formal analysis, Writing – original draft

Affiliations Graduate School, Hunan University of Chinese Medicine, Changsha, Hunan, China, Department of Emergency, Hunan Provincial Hospital of Integrated Traditional Chinese and Western Medicine (Affiliated Hospital of Hunan Academy of Traditional Chinese Medicine), Changsha, Hunan, China
⨯
Jun Deng,

Roles Data curation, Software

Affiliation Department of Neurology, Hunan Provincial Hospital of Integrated Traditional Chinese and Western Medicine (Affiliated Hospital of Hunan Academy of Traditional Chinese Medicine), Changsha, Hunan, China
⨯
Huajun Long

Roles Conceptualization, Funding acquisition, Validation, Writing – review & editing

* E-mail: longhj@hnucm.edu.cn

Affiliation Department of Emergency, Hunan Provincial Hospital of Integrated Traditional Chinese and Western Medicine (Affiliated Hospital of Hunan Academy of Traditional Chinese Medicine), Changsha, Hunan, China

https://orcid.org/0000-0002-7489-3943

⨯

Deciphering the molecular network of Trichostatin A in regulating Alzheimer’s disease screening of core genes and mechanistic investigation based on multidimensional bioinformatics and molecular simulation

Changze Ou,
Binbin Chen,
Jun Deng,
Huajun Long

Published: April 20, 2026
https://doi.org/10.1371/journal.pone.0347532

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