KIF11 promotes rheumatoid arthritis pathogenesis by activating M1 macrophage polarization and promoting inflammatory cytokine secretion

Zhaonan Ban; Yongjie Ye; Hang Zhong; Zhengjiang Li; Zhangzhen Du; Wanquan Cao; Lei Yang; Shuxing Xing

doi:10.1371/journal.pone.0347313

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Open Access

Peer-reviewed

Research Article

KIF11 promotes rheumatoid arthritis pathogenesis by activating M1 macrophage polarization and promoting inflammatory cytokine secretion

Zhaonan Ban,

Roles Investigation, Methodology, Project administration

Affiliation Department of orthopedics, the Fifth People’s Hospital of Chengdu, Chengdu, Sichuan, China
⨯
Yongjie Ye,

Roles Investigation, Software, Validation

Affiliation Department of orthopedics, the Fifth People’s Hospital of Chengdu, Chengdu, Sichuan, China
⨯
Hang Zhong,

Roles Formal analysis, Investigation, Project administration

Affiliation Department of orthopedics, the Fifth People’s Hospital of Chengdu, Chengdu, Sichuan, China
⨯
Zhengjiang Li,

Roles Formal analysis, Investigation, Software

Affiliation Department of orthopedics, the Fifth People’s Hospital of Chengdu, Chengdu, Sichuan, China
⨯
Zhangzhen Du,

Roles Data curation, Investigation, Project administration, Visualization

Affiliation Department of orthopedics, the Fifth People’s Hospital of Chengdu, Chengdu, Sichuan, China
⨯
Wanquan Cao,

Roles Formal analysis, Methodology, Software, Validation

Affiliation Department of orthopedics, the Fifth People’s Hospital of Chengdu, Chengdu, Sichuan, China
⨯
Lei Yang,

Roles Data curation, Formal analysis, Resources, Validation

Affiliation Department of orthopedics, the Fifth People’s Hospital of Chengdu, Chengdu, Sichuan, China
⨯
Shuxing Xing

Roles Conceptualization, Data curation, Resources, Visualization, Writing – original draft, Writing – review & editing

* E-mail: shxxingwork@163.com

Affiliation Department of orthopedics, the Fifth People’s Hospital of Chengdu, Chengdu, Sichuan, China

https://orcid.org/0009-0003-3375-8088

⨯

KIF11 promotes rheumatoid arthritis pathogenesis by activating M1 macrophage polarization and promoting inflammatory cytokine secretion

Zhaonan Ban,
Yongjie Ye,
Hang Zhong,
Zhengjiang Li,
Zhangzhen Du,
Wanquan Cao,
Lei Yang,
Shuxing Xing

Published: May 13, 2026
https://doi.org/10.1371/journal.pone.0347313

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