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Open Access
Peer-reviewed
Research Article
Unveiling the mechanism of calcitriol in treating type 2 diabetes mellitus: A combined network pharmacology and in vitro approach targeting ERS-related pathways
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Fanqiang Zeng ,
Contributed equally to this work with: Fanqiang Zeng, Yimei Liao
Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Visualization, Writing – original draft
Affiliation Department of Pharmacy, Guigang City People’s Hospital, The Eighth Affiliated Hospital of Guangxi Medical University, Guigang, Guangxi, China
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Yimei Liao ,
Contributed equally to this work with: Fanqiang Zeng, Yimei Liao
Roles Investigation, Methodology, Visualization
Affiliation Department of Pharmacy, Guigang City People’s Hospital, The Eighth Affiliated Hospital of Guangxi Medical University, Guigang, Guangxi, China
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Jianping Jiang,
Roles Investigation, Visualization
Affiliations Guangxi Key Laboratory of High-Quality Formation and Utilization of Dao-di Herbs, Guangxi Botanical Garden of Medicinal Plants, Nanning, Guangxi, China, Guangxi Key Laboratory of Standardized Breeding of Medicinal Animals, Guangxi Botanical Garden of Medicinal Plants, Nanning, Guangxi, China
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Chengjian Zhao,
Roles Investigation, Methodology
Affiliations Guangxi Key Laboratory of High-Quality Formation and Utilization of Dao-di Herbs, Guangxi Botanical Garden of Medicinal Plants, Nanning, Guangxi, China, Guangxi Key Laboratory of Standardized Breeding of Medicinal Animals, Guangxi Botanical Garden of Medicinal Plants, Nanning, Guangxi, China
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Shuihua Peng,
Roles Investigation
Affiliation Department of Pharmacy, Guigang City People’s Hospital, The Eighth Affiliated Hospital of Guangxi Medical University, Guigang, Guangxi, China
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Huijie Zhang,
Roles Methodology, Visualization
Affiliations Guangxi Key Laboratory of High-Quality Formation and Utilization of Dao-di Herbs, Guangxi Botanical Garden of Medicinal Plants, Nanning, Guangxi, China, Guangxi Key Laboratory of Standardized Breeding of Medicinal Animals, Guangxi Botanical Garden of Medicinal Plants, Nanning, Guangxi, China
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Hui Zou,
Roles Investigation
Affiliations Guangxi Key Laboratory of High-Quality Formation and Utilization of Dao-di Herbs, Guangxi Botanical Garden of Medicinal Plants, Nanning, Guangxi, China, Guangxi Key Laboratory of Standardized Breeding of Medicinal Animals, Guangxi Botanical Garden of Medicinal Plants, Nanning, Guangxi, China
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Shudan Tan,
Roles Investigation
Affiliations Guangxi Key Laboratory of High-Quality Formation and Utilization of Dao-di Herbs, Guangxi Botanical Garden of Medicinal Plants, Nanning, Guangxi, China, Guangxi Key Laboratory of Standardized Breeding of Medicinal Animals, Guangxi Botanical Garden of Medicinal Plants, Nanning, Guangxi, China
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Liya Qiao,
Roles Data curation, Investigation
Affiliations Guangxi Key Laboratory of High-Quality Formation and Utilization of Dao-di Herbs, Guangxi Botanical Garden of Medicinal Plants, Nanning, Guangxi, China, Guangxi Key Laboratory of Standardized Breeding of Medicinal Animals, Guangxi Botanical Garden of Medicinal Plants, Nanning, Guangxi, China
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Fan Liu,
Roles Investigation
Affiliations Guangxi Key Laboratory of High-Quality Formation and Utilization of Dao-di Herbs, Guangxi Botanical Garden of Medicinal Plants, Nanning, Guangxi, China, Guangxi Key Laboratory of Standardized Breeding of Medicinal Animals, Guangxi Botanical Garden of Medicinal Plants, Nanning, Guangxi, China
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Juan Huo,
Roles Investigation, Methodology
Affiliations Guangxi Key Laboratory of High-Quality Formation and Utilization of Dao-di Herbs, Guangxi Botanical Garden of Medicinal Plants, Nanning, Guangxi, China, Guangxi Key Laboratory of Standardized Breeding of Medicinal Animals, Guangxi Botanical Garden of Medicinal Plants, Nanning, Guangxi, China
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Zhigang Yan ,
Roles Data curation, Funding acquisition, Project administration, Writing – review & editing
* E-mail: lzg7898@163.com (ZY); xylyzg7898@126.com (YX)
Affiliations Guangxi Key Laboratory of High-Quality Formation and Utilization of Dao-di Herbs, Guangxi Botanical Garden of Medicinal Plants, Nanning, Guangxi, China, Guangxi Key Laboratory of Standardized Breeding of Medicinal Animals, Guangxi Botanical Garden of Medicinal Plants, Nanning, Guangxi, China
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Yongli Xu
Roles Data curation, Funding acquisition, Project administration, Software, Writing – review & editing
* E-mail: lzg7898@163.com (ZY); xylyzg7898@126.com (YX)
Affiliations Guangxi Key Laboratory of High-Quality Formation and Utilization of Dao-di Herbs, Guangxi Botanical Garden of Medicinal Plants, Nanning, Guangxi, China, Guangxi Key Laboratory of Standardized Breeding of Medicinal Animals, Guangxi Botanical Garden of Medicinal Plants, Nanning, Guangxi, China
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Unveiling the mechanism of calcitriol in treating type 2 diabetes mellitus: A combined network pharmacology and in vitro approach targeting ERS-related pathways
- Fanqiang Zeng,
- Yimei Liao,
- Jianping Jiang,
- Chengjian Zhao,
- Shuihua Peng,
- Huijie Zhang,
- Hui Zou,
- Shudan Tan,
- Liya Qiao,
- Fan Liu
- Published: April 16, 2026
- https://doi.org/10.1371/journal.pone.0347246