SHPRH together with the Ube2D family of enzymes directly ubiquitinates PCNA at Lys164 in vitro

• Xinyang Wang ,

  Contributed equally to this work with: Xinyang Wang, Yixiong Hu

  Roles Investigation, Writing – original draft

  Affiliation Department of Biochemistry and Molecular Biology, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), The province and ministry co-sponsored collaborative innovation center for medical epigenetics, State Key Laboratory of Experimental Hematology, Tianjin Medical University, Tianjin, P. R. CHINA

  https://orcid.org/0000-0002-3929-2667

  ⨯
• Yixiong Hu ,

  Contributed equally to this work with: Xinyang Wang, Yixiong Hu

  Roles Investigation

  Affiliation Department of Biochemistry and Molecular Biology, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), The province and ministry co-sponsored collaborative innovation center for medical epigenetics, State Key Laboratory of Experimental Hematology, Tianjin Medical University, Tianjin, P. R. CHINA

  ⨯
• Yajiao Wen,

  Roles Investigation

  Affiliation Department of Biochemistry and Molecular Biology, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), The province and ministry co-sponsored collaborative innovation center for medical epigenetics, State Key Laboratory of Experimental Hematology, Tianjin Medical University, Tianjin, P. R. CHINA

  ⨯
• Miaomiao Shen,

  Roles Investigation

  Affiliation Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center for Cancer, Tianjin’s Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, P. R. CHINA

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• Pu Chen,

  Roles Investigation, Project administration

  Affiliation Department of Biochemistry and Molecular Biology, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), The province and ministry co-sponsored collaborative innovation center for medical epigenetics, State Key Laboratory of Experimental Hematology, Tianjin Medical University, Tianjin, P. R. CHINA

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• Song Xiang

  Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing

  * E-mail: xiangsong@tmu.edu.cn

  Affiliation Department of Biochemistry and Molecular Biology, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), The province and ministry co-sponsored collaborative innovation center for medical epigenetics, State Key Laboratory of Experimental Hematology, Tianjin Medical University, Tianjin, P. R. CHINA

  https://orcid.org/0000-0001-9314-4684

  ⨯