Dysregulated lactate metabolism synergizes with ALS genetic risk factors to accelerate motor decline

Shweta Tendulkar; Tong Wu; Amy Strickland; Amber R. Hackett; Yurie Sato-Yamada; Xianrong Mao; Yo Sasaki; Jeffrey Milbrandt; A. Joseph Bloom; Aaron DiAntonio

doi:10.1371/journal.pone.0347135

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Open Access

Peer-reviewed

Research Article

Dysregulated lactate metabolism synergizes with ALS genetic risk factors to accelerate motor decline

Shweta Tendulkar,

Roles Conceptualization, Investigation, Writing – original draft, Writing – review & editing

Affiliation Department of Developmental Biology, Washington University School of Medicine, St. Louis, Missouri, United States of America

https://orcid.org/0000-0001-9305-7169

⨯
Tong Wu,

Roles Investigation

Affiliation Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯
Amy Strickland,

Roles Investigation

Affiliation Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯
Amber R. Hackett,

Roles Investigation

Affiliation Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America

https://orcid.org/0000-0002-9097-1534

⨯
Yurie Sato-Yamada,

Roles Investigation

Affiliation Center for Advanced Oral Science, Niigata University, Niigata, Japan
⨯
Xianrong Mao,

Roles Investigation

Affiliation Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯
Yo Sasaki,

Roles Investigation, Methodology, Supervision, Writing – review & editing

Affiliation Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯
Jeffrey Milbrandt,

Roles Conceptualization, Supervision, Writing – review & editing

Affiliations Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America, Needleman Center for Neurometabolism and Axonal Therapeutics, St. Louis, Missouri, United States of America
⨯
A. Joseph Bloom ,

Roles Conceptualization, Investigation, Supervision, Writing – original draft, Writing – review & editing

* E-mail: ajbloom@wustl.edu (AJB); diantonio@wustl.edu (AD)

Affiliations Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America, Needleman Center for Neurometabolism and Axonal Therapeutics, St. Louis, Missouri, United States of America

https://orcid.org/0000-0002-6731-5539

⨯
Aaron DiAntonio

Roles Conceptualization, Supervision, Writing – review & editing

* E-mail: ajbloom@wustl.edu (AJB); diantonio@wustl.edu (AD)

Affiliations Department of Developmental Biology, Washington University School of Medicine, St. Louis, Missouri, United States of America, Needleman Center for Neurometabolism and Axonal Therapeutics, St. Louis, Missouri, United States of America
⨯

Dysregulated lactate metabolism synergizes with ALS genetic risk factors to accelerate motor decline

Shweta Tendulkar,
Tong Wu,
Amy Strickland,
Amber R. Hackett,
Yurie Sato-Yamada,
Xianrong Mao,
Yo Sasaki,
Jeffrey Milbrandt,
A. Joseph Bloom,
Aaron DiAntonio

Published: April 17, 2026
https://doi.org/10.1371/journal.pone.0347135

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