Integrated RNA-seq and scRNA-seq to explore the biological mechanisms of mitophagy-related genes in ulcerative colitis

Jianguo Ma; Rongyi Xu; Yunfei Liu; Junli Shao; Jing Xu; Yan Qi

doi:10.1371/journal.pone.0346974

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Open Access

Peer-reviewed

Research Article

Integrated RNA-seq and scRNA-seq to explore the biological mechanisms of mitophagy-related genes in ulcerative colitis

Jianguo Ma ,

Roles Formal analysis, Software, Writing – original draft

¶☯ These authors contributed equally to this work and share first authorship.

Affiliation Department of Proctology, The First Affiliated Hospital of Yunnan University of Chinese Medicine/Yunnan Provincial Hospital of Traditional Chinese Medicine, Kunming, China
⨯
Rongyi Xu ,

Roles Formal analysis, Validation, Writing – original draft

¶☯ These authors contributed equally to this work and share first authorship.

Affiliation Central Laboratory, The First Affiliated Hospital of Yunnan University of Chinese Medicine/Yunnan Provincial Hospital of Traditional Chinese Medicine, Kunming, China
⨯
Yunfei Liu,

Roles Formal analysis, Methodology, Validation

Affiliation Department of Gastroenterology, The First Affiliated Hospital of Yunnan University of Chinese Medicine/Yunnan Provincial Hospital of Traditional Chinese Medicine, Kunming, China
⨯
Junli Shao,

Roles Data curation, Software, Visualization

Affiliation Central Laboratory, The First Affiliated Hospital of Yunnan University of Chinese Medicine/Yunnan Provincial Hospital of Traditional Chinese Medicine, Kunming, China
⨯
Jing Xu,

Roles Data curation, Validation

Affiliation Central Laboratory, The First Affiliated Hospital of Yunnan University of Chinese Medicine/Yunnan Provincial Hospital of Traditional Chinese Medicine, Kunming, China
⨯
Yan Qi

Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – review & editing

* E-mail: qiyankm@163.com

Affiliation Central Laboratory, The First Affiliated Hospital of Yunnan University of Chinese Medicine/Yunnan Provincial Hospital of Traditional Chinese Medicine, Kunming, China

https://orcid.org/0000-0002-7880-7790

⨯

Integrated RNA-seq and scRNA-seq to explore the biological mechanisms of mitophagy-related genes in ulcerative colitis

Jianguo Ma,
Rongyi Xu,
Yunfei Liu,
Junli Shao,
Jing Xu,
Yan Qi

Published: April 20, 2026
https://doi.org/10.1371/journal.pone.0346974

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Ulcerative colitis
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Mitochondria
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Gene expression
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Immune cells
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Colon
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Inflammatory bowel disease
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Autophagic cell death
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