Gastrodin alleviates neuronal damage in epileptic cell models by targeting P2RY12 to inhibit microglial hyperactivation

Aiyuan Cai; Zilong Li; Ran Liu; Hailong Huang; Ping Liu; Ruizhong Zhang; Jing Xiao; Yuanhong Lin; Qingpeng Hu; Haixia Wu

doi:10.1371/journal.pone.0346877

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Open Access

Peer-reviewed

Research Article

Gastrodin alleviates neuronal damage in epileptic cell models by targeting P2RY12 to inhibit microglial hyperactivation

Aiyuan Cai,

Roles Methodology, Writing – original draft

Affiliation Department of Pediatrics, Longhua District People’s Hospital, Shenzhen, Guangdong, China
⨯
Zilong Li,

Roles Methodology

Affiliation Department of Pediatrics, Longhua District People’s Hospital, Shenzhen, Guangdong, China
⨯
Ran Liu,

Roles Supervision

Affiliation Department of Pediatrics, Longhua District People’s Hospital, Shenzhen, Guangdong, China
⨯
Hailong Huang,

Roles Data curation

Affiliation Department of Pediatrics, Longhua District People’s Hospital, Shenzhen, Guangdong, China
⨯
Ping Liu,

Roles Formal analysis

Affiliation Department of Pediatrics, Longhua District People’s Hospital, Shenzhen, Guangdong, China
⨯
Ruizhong Zhang,

Roles Methodology

Affiliation Department of Pediatrics, Longhua District People’s Hospital, Shenzhen, Guangdong, China
⨯
Jing Xiao,

Roles Validation

Affiliation Department of Pediatrics, Longhua District People’s Hospital, Shenzhen, Guangdong, China
⨯
Yuanhong Lin,

Roles Methodology

Affiliation Second Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, China
⨯
Qingpeng Hu ,

Roles Writing – review & editing

* E-mail: huqingpeng163@126.com (QH); 13923430437@163.com (HW)

Affiliation Department of Pediatrics, Longhua District People’s Hospital, Shenzhen, Guangdong, China

https://orcid.org/0009-0002-0586-5364

⨯
Haixia Wu

Roles Writing – review & editing

* E-mail: huqingpeng163@126.com (QH); 13923430437@163.com (HW)

Affiliation Department of Pediatrics, Longhua District People’s Hospital, Shenzhen, Guangdong, China
⨯

Gastrodin alleviates neuronal damage in epileptic cell models by targeting P2RY12 to inhibit microglial hyperactivation

Aiyuan Cai,
Zilong Li,
Ran Liu,
Hailong Huang,
Ping Liu,
Ruizhong Zhang,
Jing Xiao,
Yuanhong Lin,
Qingpeng Hu,
Haixia Wu

Published: April 17, 2026
https://doi.org/10.1371/journal.pone.0346877

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