Acupuncture for amnestic mild cognitive impairment: Study protocol for a multicenter, single-blinded, long-term, randomized controlled trial

Xinyue Zhang; Ziwen Wang; Mingsheng Sun; Qiongnan Bao; Ziwen Chen; Yiwei Liu; Ziqi Wang; Fang Ye; Zuoqin Yang; Xiaoli Du; Hong Zhang; Xin Mou; Xia He; Dehua Li; Kexin Wu; Jin Yao; Wanqi Zhong; Ping Xu; Shiqi Yang; Ling Zhao; Zihan Yin; Fanrong Liang

doi:10.1371/journal.pone.0346717

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Acupuncture for amnestic mild cognitive impairment: Study protocol for a multicenter, single-blinded, long-term, randomized controlled trial

Xinyue Zhang ,

Contributed equally to this work with: Xinyue Zhang, Ziwen Wang, Mingsheng Sun

Roles Conceptualization, Methodology, Writing – original draft

Affiliations School of Acu-Mox and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu, China, Sichuan Provincial Acupuncture Clinical Medicine Research Center, Chengdu, China

https://orcid.org/0000-0002-2023-4053

⨯
Ziwen Wang ,

Contributed equally to this work with: Xinyue Zhang, Ziwen Wang, Mingsheng Sun

Roles Conceptualization, Methodology, Writing – original draft

Affiliations School of Acu-Mox and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu, China, Sichuan Provincial Acupuncture Clinical Medicine Research Center, Chengdu, China
⨯
Mingsheng Sun ,

Contributed equally to this work with: Xinyue Zhang, Ziwen Wang, Mingsheng Sun

Roles Conceptualization, Methodology, Writing – original draft

Affiliations School of Acu-Mox and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu, China, Sichuan Provincial Acupuncture Clinical Medicine Research Center, Chengdu, China
⨯
Qiongnan Bao,

Roles Data curation

Affiliations School of Acu-Mox and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu, China, Sichuan Provincial Acupuncture Clinical Medicine Research Center, Chengdu, China
⨯
Ziwen Chen,

Roles Data curation

Affiliations School of Acu-Mox and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu, China, Sichuan Provincial Acupuncture Clinical Medicine Research Center, Chengdu, China
⨯
Yiwei Liu,

Roles Investigation

Affiliation The West China Hospital, Chengdu, China
⨯
Ziqi Wang,

Roles Investigation

Affiliation The Fourth People’s Hospital of Chengdu, Chengdu, China
⨯
Fang Ye,

Roles Investigation

Affiliation The Sichuan Province People’s Hospital, Chengdu, China
⨯
Zuoqin Yang,

Roles Investigation

Affiliation Traditional Chinese Medicine Hospital of Pidu district, Chengdu, China
⨯
Xiaoli Du,

Roles Investigation

Affiliation The Nanchong Second People’s Hospital, Nanchong, China
⨯
Hong Zhang,

Roles Investigation

Affiliation Traditional Chinese Medicine Hospital of Meishan, Meishan, China

https://orcid.org/0000-0002-5708-7878

⨯
Xin Mou,

Roles Investigation

Affiliation Chengdu First People’s Hospital, Chengdu, China
⨯
Xia He,

Roles Investigation

Affiliation The Rehabilitation Hospital of Sichuan Province, Chengdu, China
⨯
Dehua Li,

Roles Investigation

Affiliation Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China
⨯
Kexin Wu,

Roles Data curation

Affiliations School of Acu-Mox and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu, China, Sichuan Provincial Acupuncture Clinical Medicine Research Center, Chengdu, China
⨯
Jin Yao,

Roles Data curation

Affiliations School of Acu-Mox and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu, China, Sichuan Provincial Acupuncture Clinical Medicine Research Center, Chengdu, China
⨯
Wanqi Zhong,

Roles Data curation

Affiliations School of Acu-Mox and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu, China, Sichuan Provincial Acupuncture Clinical Medicine Research Center, Chengdu, China
⨯
Ping Xu,

Roles Data curation

Affiliations School of Acu-Mox and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu, China, Sichuan Provincial Acupuncture Clinical Medicine Research Center, Chengdu, China
⨯
Shiqi Yang,

Roles Data curation

Affiliations School of Acu-Mox and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu, China, Sichuan Provincial Acupuncture Clinical Medicine Research Center, Chengdu, China
⨯
Ling Zhao ,

Roles Conceptualization, Methodology, Project administration, Supervision, Writing – review & editing

* E-mail: acuresearch@126.com (FL); yinzihan@stu.cdutcm.edu.cn (ZY); zhaoling@cdutcm.edu.cn (LZ)

Affiliations School of Acu-Mox and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu, China, Sichuan Provincial Acupuncture Clinical Medicine Research Center, Chengdu, China
⨯
Zihan Yin ,

Roles Conceptualization, Methodology, Project administration, Writing – review & editing

* E-mail: acuresearch@126.com (FL); yinzihan@stu.cdutcm.edu.cn (ZY); zhaoling@cdutcm.edu.cn (LZ)

Affiliations School of Acu-Mox and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu, China, Sichuan Provincial Acupuncture Clinical Medicine Research Center, Chengdu, China
⨯
[ ... ],
Fanrong Liang

Roles Conceptualization, Methodology, Project administration, Supervision, Writing – review & editing

* E-mail: acuresearch@126.com (FL); yinzihan@stu.cdutcm.edu.cn (ZY); zhaoling@cdutcm.edu.cn (LZ)

Affiliations School of Acu-Mox and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu, China, Sichuan Provincial Acupuncture Clinical Medicine Research Center, Chengdu, China
⨯
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Acupuncture for amnestic mild cognitive impairment: Study protocol for a multicenter, single-blinded, long-term, randomized controlled trial

Xinyue Zhang,
Ziwen Wang,
Mingsheng Sun,
Qiongnan Bao,
Ziwen Chen,
Yiwei Liu,
Ziqi Wang,
Fang Ye,
Zuoqin Yang,
Xiaoli Du

Published: April 20, 2026
https://doi.org/10.1371/journal.pone.0346717

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