The Physicochemical Synergy Effect of Nanosecond Pulsed Electric Fields (nsPEF) and cisplatin on reversing chemoresistance of bladder cancer

Danjing Guo; Xiao Li; Xiaobo Xu; Xinhua Chen; Hongqiang Cheng; Junhui Jiang

doi:10.1371/journal.pone.0346699

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Open Access

Peer-reviewed

Research Article

The Physicochemical Synergy Effect of Nanosecond Pulsed Electric Fields (nsPEF) and cisplatin on reversing chemoresistance of bladder cancer

Danjing Guo,

Roles Data curation

Affiliations Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China, NHC Key Laboratory of Combined Multi-organ Transplantation, Key Laboratory of Organ Transplantation, Hangzhou, Zhejiang, China
⨯
Xiao Li,

Roles Data curation

Affiliation Department of Urology The First Aﬃliated Hospital of Ningbo University, Ningbo, Zhejiang, China
⨯
Xiaobo Xu,

Roles Data curation, Investigation, Resources

Affiliations Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China, NHC Key Laboratory of Combined Multi-organ Transplantation, Key Laboratory of Organ Transplantation, Hangzhou, Zhejiang, China
⨯
Xinhua Chen ,

Contributed equally to this work with: Xinhua Chen, Hongqiang Cheng

Roles Funding acquisition, Resources, Writing – original draft

* E-mail: xinhua_chen@zju.edu.cn (XC); hqcheng2@hotmail.com (HC)

Affiliations Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China, NHC Key Laboratory of Combined Multi-organ Transplantation, Key Laboratory of Organ Transplantation, Hangzhou, Zhejiang, China

https://orcid.org/0000-0002-4573-9111

⨯
Hongqiang Cheng ,

Contributed equally to this work with: Xinhua Chen, Hongqiang Cheng

Roles Methodology, Supervision

* E-mail: xinhua_chen@zju.edu.cn (XC); hqcheng2@hotmail.com (HC)

Affiliation Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
⨯
Junhui Jiang

Roles Writing – review & editing

Affiliation Department of Urology The First Aﬃliated Hospital of Ningbo University, Ningbo, Zhejiang, China
⨯

The Physicochemical Synergy Effect of Nanosecond Pulsed Electric Fields (nsPEF) and cisplatin on reversing chemoresistance of bladder cancer

Danjing Guo,
Xiao Li,
Xiaobo Xu,
Xinhua Chen,
Hongqiang Cheng,
Junhui Jiang

Published: April 16, 2026
https://doi.org/10.1371/journal.pone.0346699

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Cancer treatment
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Bladder cancer
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