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Open Access
Peer-reviewed
Research Article
A comparative study of organoid-derived and cell line-derived intestinal epithelial models
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Melis Asal,
Roles Conceptualization, Data curation, Formal analysis, Methodology, Visualization, Writing – original draft, Writing – review & editing
Affiliations Department of Molecular Cell Biology and Immunology, Amsterdam UMC, Vrije Universiteit, Amsterdam, The Netherlands, Amsterdam Institute for Immunology and Infectious diseases, Amsterdam, The Netherlands
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Nanne J. Paauw,
Roles Data curation, Writing – review & editing
Affiliations Department of Molecular Cell Biology and Immunology, Amsterdam UMC, Vrije Universiteit, Amsterdam, The Netherlands, Amsterdam Institute for Immunology and Infectious diseases, Amsterdam, The Netherlands
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Hetty J. Bontkes,
Roles Conceptualization, Supervision, Writing – review & editing
Affiliations Amsterdam Institute for Immunology and Infectious diseases, Amsterdam, The Netherlands, Department of Laboratory Medicine, Laboratory Specialized Diagnostics and Research, Section Medical Immunology, Amsterdam University Medical Center, Amsterdam, The Netherlands
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Sandra J. van Vliet,
Roles Conceptualization, Supervision, Writing – review & editing
Affiliations Department of Molecular Cell Biology and Immunology, Amsterdam UMC, Vrije Universiteit, Amsterdam, The Netherlands, Amsterdam Institute for Immunology and Infectious diseases, Amsterdam, The Netherlands, Cancer Center Amsterdam, Amsterdam, The Netherlands
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Reina E. Mebius,
Roles Conceptualization, Supervision, Writing – review & editing
Affiliations Department of Molecular Cell Biology and Immunology, Amsterdam UMC, Vrije Universiteit, Amsterdam, The Netherlands, Amsterdam Institute for Immunology and Infectious diseases, Amsterdam, The Netherlands
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Susan Gibbs
Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing
* E-mail: s.gibbs@amsterdamumc.nl
Affiliations Department of Molecular Cell Biology and Immunology, Amsterdam UMC, Vrije Universiteit, Amsterdam, The Netherlands, Amsterdam Institute for Immunology and Infectious diseases, Amsterdam, The Netherlands, Department of Oral Cell Biology, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and Vrije Universiteit, Amsterdam, The Netherlands
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A comparative study of organoid-derived and cell line-derived intestinal epithelial models
- Melis Asal,
- Nanne J. Paauw,
- Hetty J. Bontkes,
- Sandra J. van Vliet,
- Reina E. Mebius,
- Susan Gibbs
- Published: April 16, 2026
- https://doi.org/10.1371/journal.pone.0346560