Machine learning-based unified models for predicting drug clearance from pharmacokinetic animal and study design variables

• Remya Ampadi Ramachandran,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations 1DATA Consortium, www.1DATA.life, Kansas State University Olathe, Olathe, Kansas, United States of America, Food Animal Residue Avoidance and Databank Program (FARAD), Kansas State University Olathe, Olathe, Kansas, United States of America, Department of Mathematics, Kansas State University, Manhattan, Kansas, United States of America

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• Lisa A. Tell,

  Roles Conceptualization, Funding acquisition, Resources, Supervision, Writing – review & editing

  Affiliation Department of Medicine and Epidemiology, FARAD, School of Veterinary Medicine, University of California-Davis, Davis, California, United States of America

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• Melissa A. Mercer,

  Roles Writing – review & editing, Validation

  Affiliation Department of Medicine and Epidemiology, FARAD, School of Veterinary Medicine, University of California-Davis, Davis, California, United States of America

  https://orcid.org/0000-0002-8112-5547

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• Xuan Xu,

  Roles Writing – review & editing, Software

  Affiliations 1DATA Consortium, www.1DATA.life, Kansas State University Olathe, Olathe, Kansas, United States of America, Department of Statistics, Kansas State University, Manhattan, United States of America

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• Nuwan Indika Millagaha Gedara,

  Roles Software, Writing – review & editing

  Affiliations 1DATA Consortium, www.1DATA.life, Kansas State University Olathe, Olathe, Kansas, United States of America, College of Business, Loyola University, New Orleans, Louisiana, United States of America

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• Maaike Ottoline Clapham,

  Roles Writing – review & editing

  Affiliation Department of Medicine and Epidemiology, FARAD, School of Veterinary Medicine, University of California-Davis, Davis, California, United States of America

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• Zhoumeng Lin,

  Roles Writing – review & editing

  Affiliations Department of Environmental and Global Health, College of Public Health and Health Professions, University of Florida, Gainesville, FL, United States of America, Center for Environmental and Human Toxicology, University of Florida, Gainesville, FL, United States of America

  https://orcid.org/0000-0002-8731-8366

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• Jim E. Riviere,

  Roles Conceptualization, Supervision, Writing – review & editing

  Affiliations 1DATA Consortium, www.1DATA.life, Kansas State University Olathe, Olathe, Kansas, United States of America, Food Animal Residue Avoidance and Databank Program (FARAD), Kansas State University Olathe, Olathe, Kansas, United States of America, Department of Population Health and Pathobiology, FARAD, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, United States of America

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• Majid Jaberi-Douraki

  Roles Conceptualization, Funding acquisition, Methodology, Project administration, Resources, Software, Supervision, Validation, Writing – review & editing

  * E-mail: jaberi@k-state.edu

  Affiliations 1DATA Consortium, www.1DATA.life, Kansas State University Olathe, Olathe, Kansas, United States of America, Food Animal Residue Avoidance and Databank Program (FARAD), Kansas State University Olathe, Olathe, Kansas, United States of America, Department of Mathematics, Kansas State University, Manhattan, Kansas, United States of America

  https://orcid.org/0000-0002-8505-6550

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