Identification of neuronatin as a SERCA2b regulin-like protein and assessment of its aggregation propensity via coarse grained simulations

Omar Ben Mariem; Lara Coppi; Emma De Fabiani; Ivano Eberini; Maurizio Crestani

doi:10.1371/journal.pone.0346335

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Peer-reviewed

Research Article

Identification of neuronatin as a SERCA2b regulin-like protein and assessment of its aggregation propensity via coarse grained simulations

Omar Ben Mariem ,

Contributed equally to this work with: Omar Ben Mariem, Lara Coppi, Ivano Eberini

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

Affiliation Dipartimento di Scienze Farmacologiche e Biomolecolari "Rodolfo Paoletti", Università degli Studi di Milano, Milano, Italy

https://orcid.org/0000-0001-5210-8089

⨯
Lara Coppi ,

Contributed equally to this work with: Omar Ben Mariem, Lara Coppi, Ivano Eberini

Roles Conceptualization, Validation, Writing – original draft, Writing – review & editing

Affiliation Dipartimento di Scienze Farmacologiche e Biomolecolari "Rodolfo Paoletti", Università degli Studi di Milano, Milano, Italy

https://orcid.org/0000-0002-6040-8863

⨯
Emma De Fabiani,

Roles Conceptualization, Funding acquisition, Validation, Writing – original draft, Writing – review & editing

Affiliation Dipartimento di Scienze Farmacologiche e Biomolecolari "Rodolfo Paoletti", Università degli Studi di Milano, Milano, Italy
⨯
Ivano Eberini ,

Contributed equally to this work with: Omar Ben Mariem, Lara Coppi, Ivano Eberini

Roles Conceptualization, Funding acquisition, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

* E-mail: ivano.eberini@unimi.it

¶‡ These authors equally contributed to this work.

Affiliation Dipartimento di Scienze Farmacologiche e Biomolecolari "Rodolfo Paoletti", Università degli Studi di Milano, Milano, Italy

https://orcid.org/0000-0001-5521-3829

⨯
Maurizio Crestani

Roles Conceptualization, Funding acquisition, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

¶‡ These authors equally contributed to this work.

Affiliation Dipartimento di Scienze Farmacologiche e Biomolecolari "Rodolfo Paoletti", Università degli Studi di Milano, Milano, Italy
⨯

Identification of neuronatin as a SERCA2b regulin-like protein and assessment of its aggregation propensity via coarse grained simulations

Omar Ben Mariem,
Lara Coppi,
Emma De Fabiani,
Ivano Eberini,
Maurizio Crestani

Published: April 9, 2026
https://doi.org/10.1371/journal.pone.0346335

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