Phytochemicals from Astragalus zederbaueri as Acetylcholinesterase Inhibitors for Alzheimer’s Therapy

Saman Asghar; Muhammad Umer Khan; Talha Jawaid; Raima Rehman; Abeeha Shafi; Abdullah R. Alzahrani; Zia Ur Rehman; Abida Khan

doi:10.1371/journal.pone.0346177

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Open Access

Peer-reviewed

Research Article

Phytochemicals from Astragalus zederbaueri as Acetylcholinesterase Inhibitors for Alzheimer’s Therapy

Saman Asghar,

Roles Formal analysis, Investigation, Methodology, Writing – original draft

Affiliation Institute of Molecular Biology and Biotechnology, The University of Lahore, Lahore, Pakistan
⨯
Muhammad Umer Khan ,

Roles Conceptualization, Project administration, Supervision, Validation, Writing – review & editing

* E-mail: muhammad.umer4@mlt.uol.edu.pk, umer.khan685@gmail.com

Affiliation Institute of Molecular Biology and Biotechnology, The University of Lahore, Lahore, Pakistan

https://orcid.org/0000-0001-6289-5207

⨯
Talha Jawaid,

Roles Funding acquisition, Resources, Software, Visualization

Affiliation Department of Pharmacology, College of Medicine, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, Saudi Arabia
⨯
Raima Rehman,

Roles Formal analysis, Validation, Visualization, Writing – original draft

Affiliation Centre of Excellence in Molecular Biology, University of the Punjab, Lahore, Pakistan
⨯
Abeeha Shafi,

Roles Software, Validation, Visualization, Writing – original draft

Affiliation Institute of Molecular Biology and Biotechnology, The University of Lahore, Lahore, Pakistan
⨯
Abdullah R. Alzahrani,

Roles Formal analysis, Project administration, Visualization, Writing – review & editing

Affiliation Department of Pharmacology and Toxicology, Faculty of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia

https://orcid.org/0000-0001-7782-0574

⨯
Zia Ur Rehman,

Roles Data curation, Formal analysis, Resources, Software

Affiliations Health Research Centre, Jazan University, Jazan, Saudi Arabia, Department of Pharmaceutical Chemistry and Pharmacognosy, Faculty of Pharmacy, Jazan University, Jazan, Saudi Arabia

https://orcid.org/0000-0002-6540-7966

⨯
Abida Khan

Roles Data curation, Formal analysis, Resources, Validation, Writing – original draft

Affiliation Center For Health Research, Northern Border University, Arar, Saudi Arabia
⨯

Phytochemicals from Astragalus zederbaueri as Acetylcholinesterase Inhibitors for Alzheimer’s Therapy

Saman Asghar,
Muhammad Umer Khan,
Talha Jawaid,
Raima Rehman,
Abeeha Shafi,
Abdullah R. Alzahrani,
Zia Ur Rehman,
Abida Khan

Published: April 10, 2026
https://doi.org/10.1371/journal.pone.0346177

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