Deciphering the synergistic mechanism of a novel flavonoid-antioxidant combination for asthma by combining systems pharmacology and experimental validation

• Ziyi Chen ,

  Contributed equally to this work with: Ziyi Chen, Xinling Ren

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Writing – original draft

  Affiliations State Key Laboratory of Respiratory Disease Shenzhen University Division, Shenzhen Key Laboratory of Allergy & Immunology, Shenzhen University School of Medicine, Shenzhen University, Shenzhen, China, Department of Respirology & Allergy, Third Affiliated Hospital of Shenzhen University, Shenzhen University, Shenzhen, China, Institute of Brain Science and Brain-inspired Research, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, P.R.China

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• Xinling Ren ,

  Contributed equally to this work with: Ziyi Chen, Xinling Ren

  Roles Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Software

  Affiliation Department of Respiratory and Critical Care Medicine, Shenzhen University General Hospital, Shenzhen, China

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• Xiaoyu Liu,

  Roles Data curation, Formal analysis, Funding acquisition, Investigation, Methodology

  Affiliation State Key Laboratory of Respiratory Disease Shenzhen University Division, Shenzhen Key Laboratory of Allergy & Immunology, Shenzhen University School of Medicine, Shenzhen University, Shenzhen, China

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• Lifeng Tian,

  Roles Formal analysis, Investigation, Validation

  Affiliation State Key Laboratory of Respiratory Disease Shenzhen University Division, Shenzhen Key Laboratory of Allergy & Immunology, Shenzhen University School of Medicine, Shenzhen University, Shenzhen, China

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• Yun Huang,

  Roles Data curation, Formal analysis, Funding acquisition, Investigation

  Affiliation Department of Respirology & Allergy, Third Affiliated Hospital of Shenzhen University, Shenzhen University, Shenzhen, China

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• Aiping Lyu ,

  Roles Investigation, Resources, Validation

  * E-mail: z_wei1005@126.com

  Affiliation School of Chinese Medicine, Hong Kong Baptist University, Kowloon, Hong Kong

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• Wei Zhou

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: z_wei1005@126.com

  Affiliations State Key Laboratory of Respiratory Disease Shenzhen University Division, Shenzhen Key Laboratory of Allergy & Immunology, Shenzhen University School of Medicine, Shenzhen University, Shenzhen, China, Department of Respirology & Allergy, Third Affiliated Hospital of Shenzhen University, Shenzhen University, Shenzhen, China

  https://orcid.org/0000-0003-2526-1904

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