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Open Access
Peer-reviewed
Research Article
Risk factors for spontaneous abortion following hepatitis E vaccination during and shortly before pregnancy: Further analysis from a cluster-randomized trial
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Asma Binte Aziz ,
Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Validation, Writing – original draft, Writing – review & editing
* E-mail: Asma.Aziz@ivi.int
Affiliations International Vaccine Institute, Seoul, Republic of Korea, International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh, Institute of Clinical Medicine, University of Oslo, Norway
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Faisal Ahmmed,
Roles Formal analysis
Affiliation International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh
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Kassa Haile,
Roles Writing – review & editing
Affiliation Armauer Hansen Research Institute, Addis Ababa, Ethiopia
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Kelvin Kering,
Roles Writing – review & editing
Affiliation Kenya Medical Research Institute (KEMRI), Nairobi, Kenya
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Susanne Dudman,
Roles Funding acquisition, Investigation, Supervision, Writing – review & editing
Affiliations Institute of Clinical Medicine, University of Oslo, Norway, Oslo University Hospital, Oslo, Norway
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Cathinka Halle Julin,
Roles Funding acquisition, Investigation, Writing – review & editing
Affiliation Oslo University Hospital, Oslo, Norway
⨯ - Joakim Øverbø,
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Ashraful Islam Khan,
Roles Writing – review & editing
Affiliation International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh
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Afroza Akter,
Roles Writing – review & editing
Affiliation International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh
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Beatrice Atieno Ongadi,
Roles Writing – review & editing
Affiliation Kenya Medical Research Institute (KEMRI), Nairobi, Kenya
⨯ -
Benjamin Ngugi,
Roles Writing – review & editing
Affiliation Kenya Medical Research Institute (KEMRI), Nairobi, Kenya
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Cecilia Kathure Mbae,
Roles Writing – review & editing
Affiliation Kenya Medical Research Institute (KEMRI), Nairobi, Kenya
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Edlawit Mesfin,
Roles Writing – review & editing
Affiliation Armauer Hansen Research Institute, Addis Ababa, Ethiopia
⨯ -
Fahima Chowdhury,
Roles Writing – review & editing
Affiliation International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh
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Farhana Khanam,
Roles Writing – review & editing
Affiliation International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh
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Joo-Young Esther Lee,
Roles Writing – review & editing
Affiliation International Vaccine Institute, Seoul, Republic of Korea
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Justin Im,
Roles Writing – review & editing
Affiliation Research Investment for Global Health Technology (RIGHT) Foundation, Seoul, Republic of Korea
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Martin Mwebia Bundi,
Roles Writing – review & editing
Affiliation Kenya Medical Research Institute (KEMRI), Nairobi, Kenya
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Md Golam Firoj,
Roles Writing – review & editing
Affiliation International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh
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Md Taufiqul Islam,
Roles Writing – review & editing
Affiliation International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh
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Moses Mwangi,
Roles Writing – review & editing
Affiliation Kenya Medical Research Institute (KEMRI), Nairobi, Kenya
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Natasha Y. Rickett,
Roles Writing – review & editing
Affiliation International Vaccine Institute, Seoul, Republic of Korea
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Sadia Isfat Ara,
Roles Writing – review & editing
Affiliation International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh
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Meseret Gebre Behute,
Roles Writing – review & editing
Affiliation International Vaccine Institute, Seoul, Republic of Korea
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Se Eun Park,
Roles Writing – review & editing
Affiliation International Vaccine Institute, Seoul, Republic of Korea
⨯ -
Suneth Agampodi,
Roles Writing – review & editing
Affiliation International Vaccine Institute, Seoul, Republic of Korea
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Samuel Kariuki,
Roles Supervision, Writing – review & editing
Affiliation Kenya Medical Research Institute (KEMRI), Nairobi, Kenya
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Suman Kanungo,
Roles Writing – review & editing
Affiliation ICMR - National Institute of Cholera and Enteric Diseases, Kolkata, West Bengal, India
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Deok Ryun Kim,
Roles Writing – review & editing
Affiliation International Vaccine Institute, Seoul, Republic of Korea
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Firdausi Qadri,
Roles Supervision, Writing – review & editing
Affiliation International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh
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Khalequ Zaman ,
Roles Funding acquisition, Methodology, Supervision, Writing – review & editing
¶☯ Contributed as joint senior author on this work.
Affiliation International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh
⨯ - [ ... ],
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John D Clemens
Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Supervision, Writing – review & editing
¶☯ Contributed as joint senior author on this work.
Affiliations International Vaccine Institute, Seoul, Republic of Korea, International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh, UCLA Fielding School of Public Health, Los Angeles, California, United States of America
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Risk factors for spontaneous abortion following hepatitis E vaccination during and shortly before pregnancy: Further analysis from a cluster-randomized trial
- Asma Binte Aziz,
- Faisal Ahmmed,
- Kassa Haile,
- Kelvin Kering,
- Susanne Dudman,
- Cathinka Halle Julin,
- Joakim Øverbø,
- Ashraful Islam Khan,
- Afroza Akter,
- Beatrice Atieno Ongadi
- Published: April 10, 2026
- https://doi.org/10.1371/journal.pone.0345974