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Open Access
Peer-reviewed
Research Article
ATRA influences the differentiation and fusion of myoblasts by regulating Rarα/Pitx2, leading to abnormal development of the pelvic floor muscles (PFMs) in fetal rats
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Hanbin Zhao,
Roles Conceptualization, Data curation, Investigation, Writing – original draft
Affiliation Department of General Surgery &Neonatal Surgery, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Engineering Research Center of Stem Cell Therapy, Children’s Hospital of Chongqing Medical University, Chongqing, P. R. China
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Jian Cao,
Roles Data curation, Investigation
Affiliation Department of General Surgery &Neonatal Surgery, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Engineering Research Center of Stem Cell Therapy, Children’s Hospital of Chongqing Medical University, Chongqing, P. R. China
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Huaqi Mu,
Roles Investigation
Affiliation Department of General Surgery &Neonatal Surgery, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Engineering Research Center of Stem Cell Therapy, Children’s Hospital of Chongqing Medical University, Chongqing, P. R. China
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Yang Bi,
Roles Methodology, Resources
Affiliation Department of General Surgery &Neonatal Surgery, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Engineering Research Center of Stem Cell Therapy, Children’s Hospital of Chongqing Medical University, Chongqing, P. R. China
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Zhenhua Guo,
Roles Project administration
Affiliation Department of General Surgery &Neonatal Surgery, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Engineering Research Center of Stem Cell Therapy, Children’s Hospital of Chongqing Medical University, Chongqing, P. R. China
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Yuan Shi ,
Roles Conceptualization, Methodology, Project administration, Supervision, Writing – review & editing
* E-mail: shiyuan@hospital.cqmu.edu.cn (YS); ddxek1994@outlook.com (YW)
Affiliation Department of Neonatology, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders, Children’s Hospital of Chongqing Medical University, Chongqing, P. R. China
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Yi Wang
Roles Conceptualization, Funding acquisition, Project administration, Resources, Supervision, Writing – review & editing
* E-mail: shiyuan@hospital.cqmu.edu.cn (YS); ddxek1994@outlook.com (YW)
Affiliation Department of General Surgery &Neonatal Surgery, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Engineering Research Center of Stem Cell Therapy, Children’s Hospital of Chongqing Medical University, Chongqing, P. R. China
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ATRA influences the differentiation and fusion of myoblasts by regulating Rarα/Pitx2, leading to abnormal development of the pelvic floor muscles (PFMs) in fetal rats
- Hanbin Zhao,
- Jian Cao,
- Huaqi Mu,
- Yang Bi,
- Zhenhua Guo,
- Yuan Shi,
- Yi Wang
- Published: April 17, 2026
- https://doi.org/10.1371/journal.pone.0345764