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Open Access

Peer-reviewed

Research Article

Pharmacophore- and QSAR-guided discovery of natural product inhibitors targeting dehydrosqualene synthase in Staphylococcus aureus

Juliana Amorim,

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Academic Unit of Health and Wellness, Universidad Católica de Cuenca, Azuay, Ecuador
⨯
Santiago Ortega,

Roles Formal analysis, Investigation, Methodology

Affiliation Academic Unit of Health and Wellness, Universidad Católica de Cuenca, Azuay, Ecuador
⨯
Ricardo Rodas,

Roles Formal analysis, Investigation, Methodology

Affiliation Academic Unit of Health and Wellness, Universidad Católica de Cuenca, Azuay, Ecuador
⨯
Luis Vélez,

Roles Formal analysis, Investigation, Methodology

Affiliation Academic Unit of Health and Wellness, Universidad Católica de Cuenca, Azuay, Ecuador
⨯
Denisse Arteaga,

Roles Formal analysis, Investigation, Methodology

Affiliation Academic Unit of Health and Wellness, Universidad Católica de Cuenca, Azuay, Ecuador
⨯
Juan Carpio

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: juanbiomarce@gmail.com

Affiliation Academic Unit of Health and Wellness, Universidad Católica de Cuenca, Azuay, Ecuador

https://orcid.org/0000-0003-3313-4905

⨯

Pharmacophore- and QSAR-guided discovery of natural product inhibitors targeting dehydrosqualene synthase in Staphylococcus aureus

Juliana Amorim,
Santiago Ortega,
Ricardo Rodas,
Luis Vélez,
Denisse Arteaga,
Juan Carpio

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Published: April 29, 2026
https://doi.org/10.1371/journal.pone.0345620

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