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Open Access
Peer-reviewed
Research Article
Glucocorticoid-Induced alterations in DNA methylation in the H19 promoter of Bone Marrow-Derived Mesenchymal Stem Cells are associated with the pathogenesis of osteonecrosis
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Song Gong ,
Contributed equally to this work with: Song Gong, Lizhi Han
Roles Conceptualization, Data curation
Affiliation Department of Orthopaedics, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
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Lizhi Han ,
Contributed equally to this work with: Song Gong, Lizhi Han
Roles Data curation, Formal analysis
Affiliations Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, Department of Orthopedics, The First Affiliated Hospital of Bengbu Medical University, Anhui Key Laboratory of Tissue Transformation, Bengbu Medical University, Bengbu, Anhui Province, P.R. China
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Yang Wang,
Roles Investigation
Affiliation Department of Orthopaedics, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
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Yong Feng,
Roles Methodology
Affiliation Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
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Ruoyu Wang,
Roles Methodology
Affiliation Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
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Shizhan Zhang,
Roles Resources, Software
Affiliation Department of Orthopaedics, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
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Kun Nie,
Roles Resources
Affiliation Department of Orthopaedics, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
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Bo Wang,
Roles Project administration
Affiliation Department of Rehabilitation, Wuhan No.1 Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China
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Fei Du,
Roles Resources
Affiliation Department of Orthopaedics, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
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Jianzhong Guan,
Roles Resources, Software
Affiliation Department of Orthopedics, The First Affiliated Hospital of Bengbu Medical University, Anhui Key Laboratory of Tissue Transformation, Bengbu Medical University, Bengbu, Anhui Province, P.R. China
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Lu Zhang ,
Roles Supervision
* E-mail: luluzhang103@hust.edu.cn (LZ); ljt73@sohu.com (JL); xuweihua@hust.edu.cn (WX)
Affiliation Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
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Jiangtao Liu ,
Roles Formal analysis, Visualization
* E-mail: luluzhang103@hust.edu.cn (LZ); ljt73@sohu.com (JL); xuweihua@hust.edu.cn (WX)
Affiliation Department of Orthopaedics, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
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Weihua Xu
Roles Writing – review & editing
* E-mail: luluzhang103@hust.edu.cn (LZ); ljt73@sohu.com (JL); xuweihua@hust.edu.cn (WX)
Affiliation Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
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Glucocorticoid-Induced alterations in DNA methylation in the H19 promoter of Bone Marrow-Derived Mesenchymal Stem Cells are associated with the pathogenesis of osteonecrosis
- Song Gong,
- Lizhi Han,
- Yang Wang,
- Yong Feng,
- Ruoyu Wang,
- Shizhan Zhang,
- Kun Nie,
- Bo Wang,
- Fei Du,
- Jianzhong Guan
- Published: March 27, 2026
- https://doi.org/10.1371/journal.pone.0345372