Myofibrillar protein accumulation but reduced protein synthesis in PDCD4-depleted myotubes

Stephen Mora; Lilia Alihemmat; Logan D. Davari; Termeh Ataie; Parsa Nafari Mehranjani; Luke Flewwelling; Arthur J. Cheng; Olasunkanmi A. J. Adegoke

doi:10.1371/journal.pone.0345305

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Open Access

Peer-reviewed

Research Article

Myofibrillar protein accumulation but reduced protein synthesis in PDCD4-depleted myotubes

Stephen Mora,

Roles Conceptualization, Formal analysis, Investigation, Writing – original draft, Writing – review & editing

Affiliation School of Kinesiology and Health Science and Muscle Health Research Centre, York University, Toronto, Ontario, Canada
⨯
Lilia Alihemmat,

Roles Formal analysis, Investigation, Writing – original draft, Writing – review & editing

Affiliation School of Kinesiology and Health Science and Muscle Health Research Centre, York University, Toronto, Ontario, Canada
⨯
Logan D. Davari,

Roles Formal analysis, Investigation, Writing – review & editing

Affiliation School of Kinesiology and Health Science and Muscle Health Research Centre, York University, Toronto, Ontario, Canada
⨯
Termeh Ataie,

Roles Formal analysis, Investigation, Writing – review & editing

Affiliation School of Kinesiology and Health Science and Muscle Health Research Centre, York University, Toronto, Ontario, Canada
⨯
Parsa Nafari Mehranjani,

Roles Formal analysis, Investigation, Writing – review & editing

Affiliation School of Kinesiology and Health Science and Muscle Health Research Centre, York University, Toronto, Ontario, Canada
⨯
Luke Flewwelling,

Roles Formal analysis, Investigation, Writing – review & editing

Affiliation School of Kinesiology and Health Science and Muscle Health Research Centre, York University, Toronto, Ontario, Canada

https://orcid.org/0000-0002-3841-7878

⨯
Arthur J. Cheng,

Roles Funding acquisition, Resources, Writing – review & editing

Affiliation School of Kinesiology and Health Science and Muscle Health Research Centre, York University, Toronto, Ontario, Canada
⨯
Olasunkanmi A. J. Adegoke

Roles Conceptualization, Funding acquisition, Investigation, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

* E-mail: oadegoke@yorku.ca

Affiliation School of Kinesiology and Health Science and Muscle Health Research Centre, York University, Toronto, Ontario, Canada

https://orcid.org/0000-0002-9697-9318

⨯

Myofibrillar protein accumulation but reduced protein synthesis in PDCD4-depleted myotubes

Stephen Mora,
Lilia Alihemmat,
Logan D. Davari,
Termeh Ataie,
Parsa Nafari Mehranjani,
Luke Flewwelling,
Arthur J. Cheng,
Olasunkanmi A. J. Adegoke

Published: March 19, 2026
https://doi.org/10.1371/journal.pone.0345305

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Protein synthesis
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Small interfering RNA
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Proteolysis
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Transfection
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Oligonucleotides
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Radioactivity
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Protein abundance
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Skeletal muscles
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