M5 positive allosteric modulation alleviates parkinsonian motor deficits

Nicole E. Chambers; Dominic Hall; Morgan Kaplan; Sarah Garan; Tyler Eichner; Mark S. Moehle

doi:10.1371/journal.pone.0345115

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Open Access

Peer-reviewed

Research Article

M₅ positive allosteric modulation alleviates parkinsonian motor deficits

Nicole E. Chambers,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing

Affiliation Department of Pharmacology and Therapeutics, Center for Translational Research in Neurodegenerative Disease, Fixel Institute University of Florida, Gainesville, Florida, United States of America
⨯
Dominic Hall,

Roles Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – review & editing

Affiliation Department of Pharmacology and Therapeutics, Center for Translational Research in Neurodegenerative Disease, Fixel Institute University of Florida, Gainesville, Florida, United States of America
⨯
Morgan Kaplan,

Roles Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – review & editing

Affiliation Department of Pharmacology and Therapeutics, Center for Translational Research in Neurodegenerative Disease, Fixel Institute University of Florida, Gainesville, Florida, United States of America
⨯
Sarah Garan,

Roles Data curation, Formal analysis, Investigation, Visualization, Writing – review & editing

Affiliation Department of Pharmacology and Therapeutics, Center for Translational Research in Neurodegenerative Disease, Fixel Institute University of Florida, Gainesville, Florida, United States of America
⨯
Tyler Eichner,

Roles Data curation, Formal analysis, Investigation, Visualization, Writing – review & editing

Affiliation Department of Pharmacology and Therapeutics, Center for Translational Research in Neurodegenerative Disease, Fixel Institute University of Florida, Gainesville, Florida, United States of America
⨯
Mark S. Moehle

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: mark.moehle@ufl.edu

Affiliation Department of Pharmacology and Therapeutics, Center for Translational Research in Neurodegenerative Disease, Fixel Institute University of Florida, Gainesville, Florida, United States of America

https://orcid.org/0000-0002-8023-1313

⨯

M₅ positive allosteric modulation alleviates parkinsonian motor deficits

Nicole E. Chambers,
Dominic Hall,
Morgan Kaplan,
Sarah Garan,
Tyler Eichner,
Mark S. Moehle

Published: March 25, 2026
https://doi.org/10.1371/journal.pone.0345115

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