Multi-omics analysis identifies CCNB1 as a cell cycle factor driving glioblastoma progression and its inhibition by resveratrol

• Bohan Liu ,

  Contributed equally to this work with: Bohan Liu, Dazhao Peng

  Roles Conceptualization, Data curation, Formal analysis, Methodology, Writing – review & editing

  Affiliations Department of Molecular Neuropathology, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China, Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China, Center of Brain Tumor, Beijing Institute for Brain Disorders, Beijing, China, China National Clinical Research Center for Neurological Diseases, Beijing, China, Chinese Glioma Genome Atlas Network (CGGA), Beijing, China, Beijing Engineering Research Center of Targeted Drugs and Cell Therapy for CNS Tumors, Beijing, P.R. China

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• Dazhao Peng ,

  Contributed equally to this work with: Bohan Liu, Dazhao Peng

  Roles Conceptualization, Data curation, Formal analysis, Methodology, Writing – review & editing

  Affiliations Department of Molecular Neuropathology, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China, Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China, Center of Brain Tumor, Beijing Institute for Brain Disorders, Beijing, China, China National Clinical Research Center for Neurological Diseases, Beijing, China, Chinese Glioma Genome Atlas Network (CGGA), Beijing, China, Beijing Engineering Research Center of Targeted Drugs and Cell Therapy for CNS Tumors, Beijing, P.R. China

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• Yankun Chen,

  Roles Methodology

  Affiliations Department of Molecular Neuropathology, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China, Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China, Center of Brain Tumor, Beijing Institute for Brain Disorders, Beijing, China, China National Clinical Research Center for Neurological Diseases, Beijing, China, Chinese Glioma Genome Atlas Network (CGGA), Beijing, China, Beijing Engineering Research Center of Targeted Drugs and Cell Therapy for CNS Tumors, Beijing, P.R. China

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• Qiuling Li,

  Roles Resources

  Affiliations Department of Molecular Neuropathology, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China, Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China, Center of Brain Tumor, Beijing Institute for Brain Disorders, Beijing, China, China National Clinical Research Center for Neurological Diseases, Beijing, China, Chinese Glioma Genome Atlas Network (CGGA), Beijing, China, Beijing Engineering Research Center of Targeted Drugs and Cell Therapy for CNS Tumors, Beijing, P.R. China

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• Yuedong Hu,

  Roles Methodology

  Affiliations Department of Molecular Neuropathology, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China, Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China, Center of Brain Tumor, Beijing Institute for Brain Disorders, Beijing, China, China National Clinical Research Center for Neurological Diseases, Beijing, China, Chinese Glioma Genome Atlas Network (CGGA), Beijing, China, Beijing Engineering Research Center of Targeted Drugs and Cell Therapy for CNS Tumors, Beijing, P.R. China

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• Shiyu Liu,

  Roles Resources

  Affiliations Department of Molecular Neuropathology, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China, Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China, Center of Brain Tumor, Beijing Institute for Brain Disorders, Beijing, China, China National Clinical Research Center for Neurological Diseases, Beijing, China, Chinese Glioma Genome Atlas Network (CGGA), Beijing, China, Beijing Engineering Research Center of Targeted Drugs and Cell Therapy for CNS Tumors, Beijing, P.R. China

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• Huimin Hu

  Roles Supervision, Validation

  * E-mail: huhm_bjni@163.com

  Affiliations Department of Molecular Neuropathology, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China, Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China, Center of Brain Tumor, Beijing Institute for Brain Disorders, Beijing, China, China National Clinical Research Center for Neurological Diseases, Beijing, China, Chinese Glioma Genome Atlas Network (CGGA), Beijing, China, Beijing Engineering Research Center of Targeted Drugs and Cell Therapy for CNS Tumors, Beijing, P.R. China

  https://orcid.org/0000-0001-5712-3624

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