Advertisement

Browse Subject Areas

?

Click through the PLOS taxonomy to find articles in your field.

For more information about PLOS Subject Areas, click here.

Loading metrics

Open Access

Peer-reviewed

Research Article

Single-cell omics reveals arg-1 as a key regulator of age-dependent macrophage-mediated cartilage repair

JianJun Chu ,

Contributed equally to this work with: JianJun Chu, Zhengfa Wen

Roles Conceptualization, Investigation, Writing – original draft

* E-mail: nadaigou@163.com

Affiliation Shaoxing Keqiao District Hospital of Traditional Chinese Medicine, Shaoxing, China

https://orcid.org/0009-0009-1078-6207

⨯
Zhengfa Wen ,

Contributed equally to this work with: JianJun Chu, Zhengfa Wen

Roles Data curation, Investigation

Affiliation Department of Orthopedics, The Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, China
⨯
Wenying Wu,

Roles Investigation, Validation

Affiliation Department of Nursing, The Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, China
⨯
Shoukun Wu

Roles Formal analysis, Validation

Affiliation Department of Orthopedics, The Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, China
⨯

Single-cell omics reveals arg-1 as a key regulator of age-dependent macrophage-mediated cartilage repair

JianJun Chu,
Zhengfa Wen,
Wenying Wu,
Shoukun Wu

x

Published: March 10, 2026
https://doi.org/10.1371/journal.pone.0344693

Reader Comments (0)

Post a new comment on this article

Print

Advertisement

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Macrophages
Is the Subject Area "Macrophages" applicable to this article?

Thanks for your feedback.
Cartilage
Is the Subject Area "Cartilage" applicable to this article?

Thanks for your feedback.
Skeletal joints
Is the Subject Area "Skeletal joints" applicable to this article?

Thanks for your feedback.
Gene expression
Is the Subject Area "Gene expression" applicable to this article?

Thanks for your feedback.
Chondrocytes
Is the Subject Area "Chondrocytes" applicable to this article?

Thanks for your feedback.
Extracellular matrix
Is the Subject Area "Extracellular matrix" applicable to this article?

Thanks for your feedback.
Tissue repair
Is the Subject Area "Tissue repair" applicable to this article?

Thanks for your feedback.
Osteoarthritis
Is the Subject Area "Osteoarthritis" applicable to this article?

Thanks for your feedback.