GBP2 promotes podocyte pyroptosis and contributes to the pathogenesis of pediatric lupus nephritis

Yu Sun; Jiahui Wei; Yanjun Zhao; Xingbo Jiang; Chao He; Xianhui Huang; Fengying Lei; Yuanhan Qin

doi:10.1371/journal.pone.0344601

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Open Access

Peer-reviewed

Research Article

GBP2 promotes podocyte pyroptosis and contributes to the pathogenesis of pediatric lupus nephritis

Yu Sun,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Department of Pediatrics, The First Affiliated Hospital of Guangxi Medical University/Guangxi Clinical Research Center for Pediatric Diseases (Focuses on Complex and Critical Cases), Nanning, China
⨯
Jiahui Wei,

Roles Data curation, Investigation, Methodology, Validation, Writing – review & editing

Affiliation Department of Pediatrics, The First Affiliated Hospital of Guangxi Medical University/Guangxi Clinical Research Center for Pediatric Diseases (Focuses on Complex and Critical Cases), Nanning, China
⨯
Yanjun Zhao,

Roles Conceptualization, Methodology, Writing – review & editing

Affiliation Department of Pediatrics, The First Affiliated Hospital of Guangxi Medical University/Guangxi Clinical Research Center for Pediatric Diseases (Focuses on Complex and Critical Cases), Nanning, China
⨯
Xingbo Jiang,

Roles Formal analysis, Methodology, Writing – review & editing

Affiliation Department of Pediatrics, The First Affiliated Hospital of Guangxi Medical University/Guangxi Clinical Research Center for Pediatric Diseases (Focuses on Complex and Critical Cases), Nanning, China
⨯
Chao He,

Roles Formal analysis, Writing – review & editing

Affiliation Department of Pediatrics, The First Affiliated Hospital of Guangxi Medical University/Guangxi Clinical Research Center for Pediatric Diseases (Focuses on Complex and Critical Cases), Nanning, China
⨯
Xianhui Huang,

Roles Formal analysis, Writing – review & editing

Affiliation Department of Pediatrics, The First Affiliated Hospital of Guangxi Medical University/Guangxi Clinical Research Center for Pediatric Diseases (Focuses on Complex and Critical Cases), Nanning, China
⨯
Fengying Lei ,

Roles Project administration, Supervision, Writing – review & editing

* E-mail: qinyuanhan2022@163.com (YHQ); fenghuang0999@163.com (FYL)

Affiliation Department of Pediatrics, The First Affiliated Hospital of Guangxi Medical University/Guangxi Clinical Research Center for Pediatric Diseases (Focuses on Complex and Critical Cases), Nanning, China
⨯
Yuanhan Qin

Roles Methodology, Project administration, Resources, Writing – review & editing

* E-mail: qinyuanhan2022@163.com (YHQ); fenghuang0999@163.com (FYL)

Affiliation Department of Pediatrics, The First Affiliated Hospital of Guangxi Medical University/Guangxi Clinical Research Center for Pediatric Diseases (Focuses on Complex and Critical Cases), Nanning, China

https://orcid.org/0000-0002-5463-8048

⨯

GBP2 promotes podocyte pyroptosis and contributes to the pathogenesis of pediatric lupus nephritis

Yu Sun,
Jiahui Wei,
Yanjun Zhao,
Xingbo Jiang,
Chao He,
Xianhui Huang,
Fengying Lei,
Yuanhan Qin

Published: March 19, 2026
https://doi.org/10.1371/journal.pone.0344601

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