Stirred tank bioreactor process for chikungunya vaccine candidate VEEV-ΔC-CHIKV

Tong Chang; ChengLin Deng; LiXia Xie; YiFan Zheng; YaNan Zhang; JiaWei Liu; ZhenFang Fu; Bo Zhang; Qi An; DaYong Tian

doi:10.1371/journal.pone.0344564

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Open Access

Peer-reviewed

Research Article

Stirred tank bioreactor process for chikungunya vaccine candidate VEEV-ΔC-CHIKV

Tong Chang,

Roles Data curation, Formal analysis, Methodology, Writing – original draft, Writing – review & editing

Affiliation R&D Department, Shanghai King-Cell Biotechnology Co., Ltd., Shanghai, Shanghai, China
⨯
ChengLin Deng,

Roles Data curation, Investigation, Methodology

Affiliation Key Laboratory of Virology and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei, China
⨯
LiXia Xie,

Roles Data curation, Formal analysis, Methodology, Validation

Affiliation R&D Department, Shanghai King-Cell Biotechnology Co., Ltd., Shanghai, Shanghai, China
⨯
YiFan Zheng,

Roles Data curation, Investigation, Methodology

Affiliation R&D Department, Shanghai King-Cell Biotechnology Co., Ltd., Shanghai, Shanghai, China
⨯
YaNan Zhang,

Roles Conceptualization, Methodology

Affiliation Key Laboratory of Virology and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei, China
⨯
JiaWei Liu,

Roles Data curation, Investigation

Affiliation R&D Department, Shanghai King-Cell Biotechnology Co., Ltd., Shanghai, Shanghai, China
⨯
ZhenFang Fu,

Roles Conceptualization, Project administration, Supervision

Affiliation R&D Department, Shanghai King-Cell Biotechnology Co., Ltd., Shanghai, Shanghai, China
⨯
Bo Zhang,

Roles Conceptualization, Formal analysis, Supervision, Validation

Affiliation Key Laboratory of Virology and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei, China
⨯
Qi An,

Roles Conceptualization, Funding acquisition, Project administration, Supervision

Affiliation R&D Department, Shanghai King-Cell Biotechnology Co., Ltd., Shanghai, Shanghai, China
⨯
DaYong Tian

Roles Conceptualization, Funding acquisition, Project administration, Supervision, Visualization, Writing – original draft, Writing – review & editing

* E-mail: tiandayong2008@163.com

Affiliation R&D Department, Shanghai King-Cell Biotechnology Co., Ltd., Shanghai, Shanghai, China

https://orcid.org/0000-0001-8978-8970

⨯

Stirred tank bioreactor process for chikungunya vaccine candidate VEEV-ΔC-CHIKV

Tong Chang,
ChengLin Deng,
LiXia Xie,
YiFan Zheng,
YaNan Zhang,
JiaWei Liu,
ZhenFang Fu,
Bo Zhang,
Qi An,
DaYong Tian

Published: March 30, 2026
https://doi.org/10.1371/journal.pone.0344564

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