Constitutive activation of TGF-β receptor type I promotes cortical and cancellous bone formation in adult mice

Tipthanan Chotipinit; Parichart Toejing; Chinnatam Phetkong; Somyoth Sridurongrit; Asada Leelahavanichkul; Julia F. Charles; Sutada Lotinun

doi:10.1371/journal.pone.0344279

Loading metrics

Open Access

Peer-reviewed

Research Article

Constitutive activation of TGF-β receptor type I promotes cortical and cancellous bone formation in adult mice

Tipthanan Chotipinit,

Roles Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft

Affiliation Center of Excellence in Skeletal Disorders and Enzyme Reaction Mechanism, Department of Physiology, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand
⨯
Parichart Toejing,

Roles Formal analysis, Investigation, Methodology, Validation

Affiliation Center of Excellence in Skeletal Disorders and Enzyme Reaction Mechanism, Department of Physiology, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand
⨯
Chinnatam Phetkong,

Roles Investigation, Methodology, Validation

Affiliation Center of Excellence in Skeletal Disorders and Enzyme Reaction Mechanism, Department of Physiology, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand
⨯
Somyoth Sridurongrit,

Roles Writing – review & editing

Affiliation Department of Anatomy, Faculty of Science, Mahidol University, Bangkok, Thailand
⨯
Asada Leelahavanichkul,

Roles Writing – review & editing

Affiliation Division of Immunology, Department of Microbiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand

https://orcid.org/0000-0002-5566-6403

⨯
Julia F. Charles,

Roles Writing – review & editing

Affiliation Departments of Orthopaedics and Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

https://orcid.org/0000-0002-5875-314X

⨯
Sutada Lotinun

Roles Conceptualization, Data curation, Funding acquisition, Project administration, Resources, Supervision, Writing – review & editing

* E-mail: sutada.l@chula.ac.th

Affiliation Center of Excellence in Skeletal Disorders and Enzyme Reaction Mechanism, Department of Physiology, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand

https://orcid.org/0000-0002-5127-3039

⨯

Constitutive activation of TGF-β receptor type I promotes cortical and cancellous bone formation in adult mice

Tipthanan Chotipinit,
Parichart Toejing,
Chinnatam Phetkong,
Somyoth Sridurongrit,
Asada Leelahavanichkul,
Julia F. Charles,
Sutada Lotinun

Published: March 2, 2026
https://doi.org/10.1371/journal.pone.0344279

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Osteoclasts
Is the Subject Area "Osteoclasts" applicable to this article?

Thanks for your feedback.
Osteoblasts
Is the Subject Area "Osteoblasts" applicable to this article?

Thanks for your feedback.
Bone development
Is the Subject Area "Bone development" applicable to this article?

Thanks for your feedback.
Osteoblast differentiation
Is the Subject Area "Osteoblast differentiation" applicable to this article?

Thanks for your feedback.
Femur
Is the Subject Area "Femur" applicable to this article?

Thanks for your feedback.
Gene expression
Is the Subject Area "Gene expression" applicable to this article?

Thanks for your feedback.
Bone resorption
Is the Subject Area "Bone resorption" applicable to this article?

Thanks for your feedback.
Cytokines
Is the Subject Area "Cytokines" applicable to this article?

Thanks for your feedback.