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Open Access
Peer-reviewed
Research Article
Association of serum irisin levels with postoperative cognitive dysfunction in older patients following total hip or knee arthroplasty: A prospective observational study
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Hongxia Zhang ,
Roles Data curation, Formal analysis, Investigation, Methodology, Software, Visualization, Writing – original draft
¶‡ co-first author.
Affiliations Department of Sterile Processing Nursing, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, Sichuan, China, School of Nursing & Anesthesiology and Critical Care Medicine Key Laboratory of Luzhou, Southwest Medical University, Luzhou, Sichuan, China
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Xue Lin ,
Roles Data curation, Investigation, Writing – original draft
¶‡ co-first author.
Affiliations School of Nursing & Anesthesiology and Critical Care Medicine Key Laboratory of Luzhou, Southwest Medical University, Luzhou, Sichuan, China, Operating room, The Affiliated Hospital, Southwest Medical University, Luzhou, Sichuan, China
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Yue Zhao ,
Roles Data curation, Investigation, Writing – original draft
¶‡ co-first author.
Affiliations School of Nursing & Anesthesiology and Critical Care Medicine Key Laboratory of Luzhou, Southwest Medical University, Luzhou, Sichuan, China, Operating room, The Affiliated Hospital, Southwest Medical University, Luzhou, Sichuan, China
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Yuting Zou ,
Roles Formal analysis, Software, Validation, Visualization
¶‡ co-first author.
Affiliations School of Nursing & Anesthesiology and Critical Care Medicine Key Laboratory of Luzhou, Southwest Medical University, Luzhou, Sichuan, China, Operating room, The Affiliated Hospital, Southwest Medical University, Luzhou, Sichuan, China
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Wei Pan ,
Roles Project administration, Supervision, Writing – review & editing
* E-mail: 491914619@qq.com (WP); yiliangying88@163.com (LY); baiyiping0608@163.com (YB); zhangdaiying202112@163.com (DZ)
Affiliations Department of Sterile Processing Nursing, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, Sichuan, China
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Liangying Yi ,
Roles Project administration, Supervision, Writing – review & editing
* E-mail: 491914619@qq.com (WP); yiliangying88@163.com (LY); baiyiping0608@163.com (YB); zhangdaiying202112@163.com (DZ)
Affiliations Department of Sterile Processing Nursing, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, Sichuan, China
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Yiping Bai ,
Roles Conceptualization, Methodology, Project administration, Supervision, Writing – review & editing
* E-mail: 491914619@qq.com (WP); yiliangying88@163.com (LY); baiyiping0608@163.com (YB); zhangdaiying202112@163.com (DZ)
Affiliations School of Nursing & Anesthesiology and Critical Care Medicine Key Laboratory of Luzhou, Southwest Medical University, Luzhou, Sichuan, China, Operating room, The Affiliated Hospital, Southwest Medical University, Luzhou, Sichuan, China, Department of Anesthesiology, The Affiliated Hospital, Southwest Medical University, Luzhou, Sichuan, China
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Daiying Zhang
Roles Conceptualization, Data curation, Funding acquisition, Methodology, Project administration, Supervision, Writing – review & editing
* E-mail: 491914619@qq.com (WP); yiliangying88@163.com (LY); baiyiping0608@163.com (YB); zhangdaiying202112@163.com (DZ)
Affiliations School of Nursing & Anesthesiology and Critical Care Medicine Key Laboratory of Luzhou, Southwest Medical University, Luzhou, Sichuan, China, Operating room, The Affiliated Hospital, Southwest Medical University, Luzhou, Sichuan, China, Department of Anesthesiology, The Affiliated Hospital, Southwest Medical University, Luzhou, Sichuan, China
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Association of serum irisin levels with postoperative cognitive dysfunction in older patients following total hip or knee arthroplasty: A prospective observational study
- Hongxia Zhang,
- Xue Lin,
- Yue Zhao,
- Yuting Zou,
- Wei Pan,
- Liangying Yi,
- Yiping Bai,
- Daiying Zhang
- Published: April 10, 2026
- https://doi.org/10.1371/journal.pone.0344177