Reduced levels of mitochondrial ribosomal protein MRPL54 does not alter Apc related adenoma formation

Claudia N. Spaan; Eileen Daniels; Wouter L. Smit; Ruben J. de Boer; Joana Silva; Jacqueline L. M. Vermeulen; S. Meisner; Vanesa Muncan; Riekelt H. Houtkooper; Jarom Heijmans

doi:10.1371/journal.pone.0344161

Loading metrics

Open Access

Peer-reviewed

Research Article

Reduced levels of mitochondrial ribosomal protein MRPL54 does not alter Apc related adenoma formation

Claudia N. Spaan ,

Contributed equally to this work with: Claudia N. Spaan, Eileen Daniels

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliations Amsterdam UMC, University of Amsterdam, department of Gastroenterology and Hepatology, Tytgat Institute for Liver and Intestinal Research, Amsterdam, Netherlands, Cancer Center Amsterdam, Cancer Biology and Immunology, Amsterdam, The Netherlands

https://orcid.org/0000-0001-7557-5827

⨯
Eileen Daniels ,

Contributed equally to this work with: Claudia N. Spaan, Eileen Daniels

Roles Conceptualization, Data curation, Formal analysis, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliations Laboratory Genetic Metabolic Diseases, Amsterdam UMC location University of Amsterdam, The Netherlands, Amsterdam Gastroenterology Endocrinology and Metabolism institute, Amsterdam, The Netherlands
⨯
Wouter L. Smit,

Roles Conceptualization, Data curation, Formal analysis, Investigation

Affiliations Amsterdam UMC, University of Amsterdam, department of Gastroenterology and Hepatology, Tytgat Institute for Liver and Intestinal Research, Amsterdam, Netherlands, Cancer Center Amsterdam, Cancer Biology and Immunology, Amsterdam, The Netherlands
⨯
Ruben J. de Boer,

Roles Formal analysis, Investigation

Affiliations Amsterdam UMC, University of Amsterdam, department of Gastroenterology and Hepatology, Tytgat Institute for Liver and Intestinal Research, Amsterdam, Netherlands, Cancer Center Amsterdam, Cancer Biology and Immunology, Amsterdam, The Netherlands
⨯
Joana Silva,

Roles Data curation, Methodology, Resources, Writing – review & editing

Affiliation Department of Oncogenomics, Netherlands Cancer Institute, Amsterdam, The Netherlands
⨯
Jacqueline L. M. Vermeulen,

Roles Formal analysis, Investigation

Affiliation Amsterdam UMC, University of Amsterdam, department of Gastroenterology and Hepatology, Tytgat Institute for Liver and Intestinal Research, Amsterdam, Netherlands
⨯
S. Meisner,

Roles Formal analysis, Investigation

Affiliation Amsterdam UMC, University of Amsterdam, department of Gastroenterology and Hepatology, Tytgat Institute for Liver and Intestinal Research, Amsterdam, Netherlands
⨯
Vanesa Muncan,

Roles Conceptualization, Formal analysis, Project administration, Supervision, Validation, Writing – review & editing

Affiliation Amsterdam UMC, University of Amsterdam, department of Gastroenterology and Hepatology, Tytgat Institute for Liver and Intestinal Research, Amsterdam, Netherlands
⨯
Riekelt H. Houtkooper,

Roles Conceptualization, Formal analysis, Funding acquisition, Project administration, Supervision, Writing – original draft, Writing – review & editing

Affiliations Laboratory Genetic Metabolic Diseases, Amsterdam UMC location University of Amsterdam, The Netherlands, Amsterdam Gastroenterology Endocrinology and Metabolism institute, Amsterdam, The Netherlands, Amsterdam Cardiovascular Sciences institute, Amsterdam, The Netherlands, Emma Center for Personalized Medicine, Amsterdam UMC, Amsterdam, The Netherlands
⨯
Jarom Heijmans

Roles Conceptualization, Formal analysis, Funding acquisition, Project administration, Supervision, Writing – original draft, Writing – review & editing

* E-mail: j.heijmans@amsterdamUMC.nl

Affiliations Amsterdam UMC, University of Amsterdam, department of Gastroenterology and Hepatology, Tytgat Institute for Liver and Intestinal Research, Amsterdam, Netherlands, Cancer Center Amsterdam, Cancer Biology and Immunology, Amsterdam, The Netherlands, Amsterdam Gastroenterology Endocrinology and Metabolism institute, Amsterdam, The Netherlands
⨯

Reduced levels of mitochondrial ribosomal protein MRPL54 does not alter Apc related adenoma formation

Claudia N. Spaan,
Eileen Daniels,
Wouter L. Smit,
Ruben J. de Boer,
Joana Silva,
Jacqueline L. M. Vermeulen,
S. Meisner,
Vanesa Muncan,
Riekelt H. Houtkooper,
Jarom Heijmans

Published: March 9, 2026
https://doi.org/10.1371/journal.pone.0344161

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Adenomas
Is the Subject Area "Adenomas" applicable to this article?

Thanks for your feedback.
Colorectal cancer
Is the Subject Area "Colorectal cancer" applicable to this article?

Thanks for your feedback.
Heterozygosity
Is the Subject Area "Heterozygosity" applicable to this article?

Thanks for your feedback.
Gastrointestinal tract
Is the Subject Area "Gastrointestinal tract" applicable to this article?

Thanks for your feedback.
Gastrointestinal cancers
Is the Subject Area "Gastrointestinal cancers" applicable to this article?

Thanks for your feedback.
Mitochondria
Is the Subject Area "Mitochondria" applicable to this article?

Thanks for your feedback.
Antigen-presenting cells
Is the Subject Area "Antigen-presenting cells" applicable to this article?

Thanks for your feedback.
Mouse models
Is the Subject Area "Mouse models" applicable to this article?

Thanks for your feedback.