A dimer peptide ligand of vascular endothelial growth factor slows the progression of human gastric tumors in mouse xenografts

Xiaoqing Ye; Haofeng Hu; Yilei He; Fei Ye; Jia Jin; Elodie Olivier; Jean-François Gaucher; Lei Wang; Sylvain Broussy

doi:10.1371/journal.pone.0344142

Loading metrics

Open Access

Peer-reviewed

Research Article

A dimer peptide ligand of vascular endothelial growth factor slows the progression of human gastric tumors in mouse xenografts

Xiaoqing Ye ,

Contributed equally to this work with: Xiaoqing Ye, Haofeng Hu

Roles Formal analysis, Investigation, Writing – original draft, Writing – review & editing

Affiliation School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou, China
⨯
Haofeng Hu ,

Contributed equally to this work with: Xiaoqing Ye, Haofeng Hu

Roles Formal analysis, Investigation, Methodology, Writing – review & editing

Affiliation Université Paris Cité, CNRS, Inserm, CiTCoM, Paris, France
⨯
Yilei He,

Roles Investigation, Writing – review & editing

Affiliation College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou, China
⨯
Fei Ye,

Roles Funding acquisition, Writing – review & editing

Affiliation College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou, China
⨯
Jia Jin,

Roles Funding acquisition, Writing – review & editing

Affiliation College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou, China

https://orcid.org/0000-0003-3315-4797

⨯
Elodie Olivier,

Roles Formal analysis, Investigation, Resources, Writing – review & editing

Affiliation Université Paris Cité, CNRS, CiTCoM, Paris, France

https://orcid.org/0000-0002-6566-8170

⨯
Jean-François Gaucher,

Roles Formal analysis, Supervision, Writing – review & editing

Affiliation Université Paris Cité, CNRS, CiTCoM, Paris, France
⨯
Lei Wang ,

Roles Conceptualization, Formal analysis, Funding acquisition, Supervision, Writing – original draft, Writing – review & editing

* E-mail: leiwang1986@hotmail.com (LW); sylvain.broussy@u-paris.fr (SB)

Affiliation College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou, China
⨯
Sylvain Broussy

Roles Conceptualization, Formal analysis, Funding acquisition, Supervision, Writing – original draft, Writing – review & editing

* E-mail: leiwang1986@hotmail.com (LW); sylvain.broussy@u-paris.fr (SB)

Affiliation Université Paris Cité, CNRS, Inserm, CiTCoM, Paris, France

https://orcid.org/0000-0003-3098-5317

⨯

A dimer peptide ligand of vascular endothelial growth factor slows the progression of human gastric tumors in mouse xenografts

Xiaoqing Ye,
Haofeng Hu,
Yilei He,
Fei Ye,
Jia Jin,
Elodie Olivier,
Jean-François Gaucher,
Lei Wang,
Sylvain Broussy

Published: August 3, 2026
https://doi.org/10.1371/journal.pone.0344142

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Gastric cancer
Is the Subject Area "Gastric cancer" applicable to this article?

Thanks for your feedback.
Cancer treatment
Is the Subject Area "Cancer treatment" applicable to this article?

Thanks for your feedback.
Mouse models
Is the Subject Area "Mouse models" applicable to this article?

Thanks for your feedback.
Peptide synthesis
Is the Subject Area "Peptide synthesis" applicable to this article?

Thanks for your feedback.
Analysis of variance
Is the Subject Area "Analysis of variance" applicable to this article?

Thanks for your feedback.
Cell proliferation
Is the Subject Area "Cell proliferation" applicable to this article?

Thanks for your feedback.
Dimers
Is the Subject Area "Dimers" applicable to this article?

Thanks for your feedback.
Receptor antagonist therapy
Is the Subject Area "Receptor antagonist therapy" applicable to this article?

Thanks for your feedback.