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Open Access

Peer-reviewed

Research Article

Identification of autophagy-related key biomarkers in caerulein induced acute pancreatitis: In silico and in vivo study

Xinzhuang Shen,

Roles Writing – original draft

Affiliation Department of General Surgery, Affiliated Hospital of Jining Medical University, Jining, People’s Republic of China
⨯
Jie Yao,

Roles Writing – original draft

Affiliation Jining Hospital of Traditional Chinese Medicine, Xiyuan Hospital of China Academy of Chinese Medical Sciences, Jining, People’s Republic of China
⨯
Zongke Wang,

Roles Software

Affiliation Department of Critical Care Medicine, Affiliated Hospital of Jining Medical University, Jining, People’s Republic of China
⨯
Renhua Chen,

Roles Methodology

Affiliation Key Laboratory of Precision Oncology in Universities of Shandong, Institute of Precision Medicine, Jining Medical University, Jining, China
⨯
Laian Li,

Roles Software

Affiliation Department of General Surgery, Affiliated Hospital of Jining Medical University, Jining, People’s Republic of China
⨯
Xiangjun Xu,

Roles Software

Affiliation Department of General Surgery, Affiliated Hospital of Jining Medical University, Jining, People’s Republic of China
⨯
Yongming Huang

Roles Resources, Writing – review & editing

* E-mail: huangym0524@163.com

Affiliations Department of General Surgery, Affiliated Hospital of Jining Medical University, Jining, People’s Republic of China, Key Laboratory of Hepatosplenic Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, People’s Republic of China

https://orcid.org/0000-0002-5955-3457

⨯

Identification of autophagy-related key biomarkers in caerulein induced acute pancreatitis: In silico and in vivo study

Xinzhuang Shen,
Jie Yao,
Zongke Wang,
Renhua Chen,
Laian Li,
Xiangjun Xu,
Yongming Huang

x

Published: March 27, 2026
https://doi.org/10.1371/journal.pone.0344110

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Autophagic cell death
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Gene expression
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Pancreatitis
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Protein structure databases
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Principal component analysis
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Protein expression
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Biomarkers
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Drug interactions
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