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Open Access
Peer-reviewed
Research Article
Exendin-4 enhances GLP-1 signaling and reduces anxiety-like behaviors in male heroin withdrawal mice
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Yang Xiang ,
Contributed equally to this work with: Yang Xiang, Xiaowei Yan
Roles Conceptualization, Data curation, Investigation, Methodology, Project administration, Software, Writing – original draft, Writing – review & editing
Affiliation Department of Histology and Embryology, School of Basic Medical Sciences, Guizhou Medical University, Gui’an New District, Guizhou, China
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Xiaowei Yan ,
Contributed equally to this work with: Yang Xiang, Xiaowei Yan
Roles Conceptualization, Methodology, Resources, Software, Writing – original draft
Affiliation Department of Histology and Embryology, School of Basic Medical Sciences, Guizhou Medical University, Gui’an New District, Guizhou, China
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Rongrong Li,
Roles Funding acquisition, Investigation, Methodology, Software, Writing – review & editing
Affiliation Department of Histology and Embryology, School of Basic Medical Sciences, Guizhou Medical University, Gui’an New District, Guizhou, China
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Chunlu Li,
Roles Conceptualization, Methodology, Software, Writing – review & editing
Affiliation Department of Histology and Embryology, School of Basic Medical Sciences, Guizhou Medical University, Gui’an New District, Guizhou, China
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Dan Yin,
Roles Data curation, Formal analysis, Methodology, Resources
Affiliation Department of Histology and Embryology, School of Basic Medical Sciences, Guizhou Medical University, Gui’an New District, Guizhou, China
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Cancan Luo,
Roles Conceptualization, Investigation, Methodology, Software
Affiliation Department of Histology and Embryology, School of Basic Medical Sciences, Guizhou Medical University, Gui’an New District, Guizhou, China
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Yingqi Xiong,
Roles Conceptualization, Software, Writing – original draft
Affiliation Department of Histology and Embryology, School of Basic Medical Sciences, Guizhou Medical University, Gui’an New District, Guizhou, China
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Yan Hong ,
Roles Conceptualization, Methodology, Project administration, Writing – review & editing
* E-mail: xiabaijuan4191@163.com (BX); hongyanb@163.com (YH); liyixin@gmc.ed.cn (YL)
Affiliation Department of Histology and Embryology, School of Basic Medical Sciences, Guizhou Medical University, Gui’an New District, Guizhou, China
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Yixin Li ,
Roles Data curation, Formal analysis, Funding acquisition, Resources, Writing – review & editing
* E-mail: xiabaijuan4191@163.com (BX); hongyanb@163.com (YH); liyixin@gmc.ed.cn (YL)
Affiliation Department of Histology and Embryology, School of Basic Medical Sciences, Guizhou Medical University, Gui’an New District, Guizhou, China
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Baijuan Xia
Roles Data curation, Funding acquisition, Project administration, Software, Validation, Writing – review & editing
* E-mail: xiabaijuan4191@163.com (BX); hongyanb@163.com (YH); liyixin@gmc.ed.cn (YL)
Affiliation Department of Histology and Embryology, School of Basic Medical Sciences, Guizhou Medical University, Gui’an New District, Guizhou, China
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Exendin-4 enhances GLP-1 signaling and reduces anxiety-like behaviors in male heroin withdrawal mice
- Yang Xiang,
- Xiaowei Yan,
- Rongrong Li,
- Chunlu Li,
- Dan Yin,
- Cancan Luo,
- Yingqi Xiong,
- Yan Hong,
- Yixin Li,
- Baijuan Xia
- Published: March 12, 2026
- https://doi.org/10.1371/journal.pone.0343995