Temporal dynamics and functional annotation of transcriptome rhythmicity in HEK293T cells

Yuling Sun; Huiyu Dong; Fei Ge; Ying Zhao; Shuhan Yang; Yidong Ding; Min Dong; Liming Wang; Tao Zhang

doi:10.1371/journal.pone.0343991

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Open Access

Peer-reviewed

Research Article

Temporal dynamics and functional annotation of transcriptome rhythmicity in HEK293T cells

Yuling Sun ,

Contributed equally to this work with: Yuling Sun, Huiyu Dong, Fei Ge

Roles Data curation, Formal analysis, Investigation, Writing – original draft, Writing – review & editing

Affiliation Jiangsu Province Engineering Research Center of Development and Translation of Key Technologies for Chronic Disease Prevention and Control, Suzhou Vocational Health College, Suzhou, China
⨯
Huiyu Dong ,

Contributed equally to this work with: Yuling Sun, Huiyu Dong, Fei Ge

Roles Data curation, Formal analysis, Investigation, Writing – review & editing

Affiliation Department of Clinical Medicine, Suzhou Vocational Health College, Suzhou, China
⨯
Fei Ge ,

Contributed equally to this work with: Yuling Sun, Huiyu Dong, Fei Ge

Roles Data curation, Formal analysis, Funding acquisition, Investigation, Writing – original draft, Writing – review & editing

Affiliation Department of Basic Medicine, Suzhou Vocational Health College, Suzhou, China
⨯
Ying Zhao,

Roles Data curation, Formal analysis, Funding acquisition, Investigation, Writing – review & editing

Affiliation Jiangsu Province Engineering Research Center of Development and Translation of Key Technologies for Chronic Disease Prevention and Control, Suzhou Vocational Health College, Suzhou, China
⨯
Shuhan Yang,

Roles Data curation, Formal analysis, Writing – review & editing

Affiliation Jiangsu Province Engineering Research Center of Development and Translation of Key Technologies for Chronic Disease Prevention and Control, Suzhou Vocational Health College, Suzhou, China
⨯
Yidong Ding,

Roles Data curation, Project administration, Writing – review & editing

Affiliation Department of Clinical Medicine, Suzhou Vocational Health College, Suzhou, China
⨯
Min Dong,

Roles Data curation, Project administration, Writing – review & editing

Affiliation Department of Basic Medicine, Suzhou Vocational Health College, Suzhou, China
⨯
Liming Wang ,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Resources, Writing – original draft, Writing – review & editing

* E-mail: zhangtao@szhct.edu.cn (TZ); windywave@163.com (LW)

Affiliation Department of Basic Medicine, Suzhou Vocational Health College, Suzhou, China
⨯
Tao Zhang

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Project administration, Supervision, Writing – original draft, Writing – review & editing

* E-mail: zhangtao@szhct.edu.cn (TZ); windywave@163.com (LW)

Affiliation Jiangsu Province Engineering Research Center of Development and Translation of Key Technologies for Chronic Disease Prevention and Control, Suzhou Vocational Health College, Suzhou, China

https://orcid.org/0000-0002-1163-9470

⨯

Temporal dynamics and functional annotation of transcriptome rhythmicity in HEK293T cells

Yuling Sun,
Huiyu Dong,
Fei Ge,
Ying Zhao,
Shuhan Yang,
Yidong Ding,
Min Dong,
Liming Wang,
Tao Zhang

Published: February 26, 2026
https://doi.org/10.1371/journal.pone.0343991

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Transcriptome analysis
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Circadian rhythms
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Circadian oscillators
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Gene expression
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Genetic oscillators
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DNA transcription
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Guanosine triphosphatase
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Gene regulation
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