Integrated network pharmacology and comprehensive bioinformatics analysis to identify the mechanisms and molecular targets of ketamine in ischemic stroke–depression comorbidity

Yunfei Shu; Yinhao Guo; Suihan Xu; Hongxia He; Biao Zeng; Zhenyu Yang; Wei Gao; Jun Li

doi:10.1371/journal.pone.0343918

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Open Access

Peer-reviewed

Research Article

Integrated network pharmacology and comprehensive bioinformatics analysis to identify the mechanisms and molecular targets of ketamine in ischemic stroke–depression comorbidity

Yunfei Shu,

Roles Data curation, Formal analysis, Investigation, Software, Visualization

Affiliations Mianyang Key Laboratory of Anesthesia and Neuroregulation, Department of Anesthesiology, Mianyang Central Hospital, Mianyang, China, Department of Anesthesiology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, People’s Republic of China
⨯
Yinhao Guo,

Roles Investigation

Affiliation Mianyang Key Laboratory of Anesthesia and Neuroregulation, Department of Anesthesiology, Mianyang Central Hospital, Mianyang, China
⨯
Suihan Xu,

Roles Resources

Affiliation Mianyang Key Laboratory of Anesthesia and Neuroregulation, Department of Anesthesiology, Mianyang Central Hospital, Mianyang, China
⨯
Hongxia He,

Roles Software

Affiliation Mianyang Key Laboratory of Anesthesia and Neuroregulation, Department of Anesthesiology, Mianyang Central Hospital, Mianyang, China
⨯
Biao Zeng,

Roles Validation

Affiliation Mianyang Key Laboratory of Anesthesia and Neuroregulation, Department of Anesthesiology, Mianyang Central Hospital, Mianyang, China
⨯
Zhenyu Yang,

Roles Visualization

Affiliation Mianyang Key Laboratory of Anesthesia and Neuroregulation, Department of Anesthesiology, Mianyang Central Hospital, Mianyang, China
⨯
Wei Gao ,

Roles Funding acquisition

* E-mail: gaowei2906@xjtufh.edu.cn (WG); lj89199@uestc.edu.cn (JL)

Affiliation Department of Anesthesiology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, People’s Republic of China
⨯
Jun Li

Roles Conceptualization, Methodology, Project administration, Supervision, Writing – review & editing

* E-mail: gaowei2906@xjtufh.edu.cn (WG); lj89199@uestc.edu.cn (JL)

Affiliation Mianyang Key Laboratory of Anesthesia and Neuroregulation, Department of Anesthesiology, Mianyang Central Hospital, Mianyang, China

https://orcid.org/0000-0003-3971-2083

⨯

Integrated network pharmacology and comprehensive bioinformatics analysis to identify the mechanisms and molecular targets of ketamine in ischemic stroke–depression comorbidity

Yunfei Shu,
Yinhao Guo,
Suihan Xu,
Hongxia He,
Biao Zeng,
Zhenyu Yang,
Wei Gao,
Jun Li

Published: March 18, 2026
https://doi.org/10.1371/journal.pone.0343918

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