Effects of tacrolimus treatment on the gut microbiota and metabolites in liver transplant recipients

Guohui Wang; Lu Liu; Hanshu Zhang; Panpan Mao; Saijuan Lu; Xiaofang Zhang; Xingde Li; Cangsang Song

doi:10.1371/journal.pone.0343817

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Open Access

Peer-reviewed

Research Article

Effects of tacrolimus treatment on the gut microbiota and metabolites in liver transplant recipients

Guohui Wang ,

Contributed equally to this work with: Guohui Wang, Lu Liu

Roles Conceptualization, Project administration, Writing – original draft

¶‡ These authors are co-first authors on this work.

Affiliation Department of Pharmacy, The First People’s Hospital of Kunming City and Calmette Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China

https://orcid.org/0009-0009-3156-9949

⨯
Lu Liu ,

Contributed equally to this work with: Guohui Wang, Lu Liu

Roles Data curation, Investigation

¶‡ These authors are co-first authors on this work.

Affiliation Department of Pharmacy, The First People’s Hospital of Kunming City and Calmette Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China
⨯
Hanshu Zhang,

Roles Formal analysis

Affiliation Department of Pharmacy, The First People’s Hospital of Kunming City and Calmette Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China
⨯
Panpan Mao,

Roles Data curation

Affiliation Department of Pharmacy, The First People’s Hospital of Kunming City and Calmette Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China
⨯
Saijuan Lu,

Roles Methodology

Affiliation Department of Pharmacy, The First People’s Hospital of Kunming City and Calmette Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China
⨯
Xiaofang Zhang,

Roles Validation

Affiliation Department of Pharmacy, The First People’s Hospital of Kunming City and Calmette Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China
⨯
Xingde Li ,

Roles Project administration, Supervision

* E-mail: smart1103@163.com (XL); songcs163@163.com (CS)

Affiliation Department of Pharmacy, The First People’s Hospital of Kunming City and Calmette Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China
⨯
Cangsang Song

Roles Funding acquisition, Project administration

* E-mail: smart1103@163.com (XL); songcs163@163.com (CS)

Affiliation Department of Pharmacy, The First People’s Hospital of Kunming City and Calmette Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China
⨯

Effects of tacrolimus treatment on the gut microbiota and metabolites in liver transplant recipients

Guohui Wang,
Lu Liu,
Hanshu Zhang,
Panpan Mao,
Saijuan Lu,
Xiaofang Zhang,
Xingde Li,
Cangsang Song

Published: February 26, 2026
https://doi.org/10.1371/journal.pone.0343817

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Gut bacteria
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