Based on single-cell and transcriptome analysis of inflammatory pathway biomarkers and their molecular mechanisms in chronic obstructive pulmonary disease

Yaping Zhou; Hui Gong; Zelin Hao; Lu Wang; Li Li; Xiaoguang Zou

doi:10.1371/journal.pone.0343798

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Open Access

Peer-reviewed

Research Article

Based on single-cell and transcriptome analysis of inflammatory pathway biomarkers and their molecular mechanisms in chronic obstructive pulmonary disease

Yaping Zhou ,

Contributed equally to this work with: Yaping Zhou, Hui Gong, Zelin Hao

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

Affiliation The Affiliated Teaching Hospital of Xinjiang Medical University (Affiliated Cancer Hospital), Urumqi, China
⨯
Hui Gong ,

Contributed equally to this work with: Yaping Zhou, Hui Gong, Zelin Hao

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Visualization, Writing – original draft, Writing – review & editing

Affiliation Clinical Research Center of Infectious Diseases (Pulmonary Tuberculosis), First People′s Hospital of Kashi, Kashi, China
⨯
Zelin Hao ,

Contributed equally to this work with: Yaping Zhou, Hui Gong, Zelin Hao

Roles Conceptualization, Data curation, Formal analysis, Investigation, Resources, Software, Supervision, Validation, Visualization, Writing – original draft

Affiliation Department of Respiratory and Critical Care Medicine, First People′s Hospital of Kashi, Kashi, China
⨯
Lu Wang,

Roles Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization

Affiliation Department of Laboratory Medicine, People’s Hospital of Bayingol Mongolian Autonomous Prefecture, Korla, China
⨯
Li Li ,

Roles Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: lili5511@yeah.net (LL); zxg5665@163.com (XZ)

Affiliation Department of Respiratory and Critical Care Medicine, First People′s Hospital of Kashi, Kashi, China
⨯
Xiaoguang Zou

Roles Conceptualization, Formal analysis, Funding acquisition, Resources, Supervision, Writing – review & editing

* E-mail: lili5511@yeah.net (LL); zxg5665@163.com (XZ)

Affiliation Department of Respiratory and Critical Care Medicine, First People′s Hospital of Kashi, Kashi, China

https://orcid.org/0009-0007-6594-2348

⨯

Based on single-cell and transcriptome analysis of inflammatory pathway biomarkers and their molecular mechanisms in chronic obstructive pulmonary disease

Yaping Zhou,
Hui Gong,
Zelin Hao,
Lu Wang,
Li Li,
Xiaoguang Zou

Published: February 25, 2026
https://doi.org/10.1371/journal.pone.0343798

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Chronic obstructive pulmonary disease
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Macrophages
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Inflammatory diseases
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Gene expression
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Immune cells
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