A kappa opioid receptor agonist, difelikefalin, improves acute kidney injury in experimental sepsis models

• Yoshiharu Sawanobori ,

  Contributed equally to this work with: Yoshiharu Sawanobori, Daisuke Nakano, Hiroaki Kitamura, Kento Kitada

  Roles Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Resources, Validation, Visualization, Writing – original draft

  Affiliations Department of Anesthesiology, Kagawa University, Kagawa, Japan, Department of Pharmacology, Kagawa University, Kagawa, Japan

  ⨯
• Daisuke Nakano ,

  Contributed equally to this work with: Yoshiharu Sawanobori, Daisuke Nakano, Hiroaki Kitamura, Kento Kitada

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Methodology, Project administration, Supervision, Writing – review & editing

  * E-mail: dnakano28@gmail.com

  Affiliation Department of Pharmacology, Kagawa University, Kagawa, Japan

  https://orcid.org/0000-0002-7435-8465

  ⨯
• Hiroaki Kitamura ,

  Contributed equally to this work with: Yoshiharu Sawanobori, Daisuke Nakano, Hiroaki Kitamura, Kento Kitada

  Roles Funding acquisition

  Affiliation Department of Anesthesiology, Kagawa University, Kagawa, Japan

  ⨯
• Kento Kitada ,

  Contributed equally to this work with: Yoshiharu Sawanobori, Daisuke Nakano, Hiroaki Kitamura, Kento Kitada

  Roles Supervision, Writing – review & editing

  Affiliation Department of Pharmacology, Kagawa University, Kagawa, Japan

  ⨯
• Takehiko Asaga ,

  Roles Funding acquisition

  ¶‡ TA, NS, MY, YO, GS and AN also contributed equally to this work.

  Affiliation Department of Anesthesiology, Kagawa University, Kagawa, Japan

  ⨯
• Norio Suzuki ,

  Roles Resources

  ¶‡ TA, NS, MY, YO, GS and AN also contributed equally to this work.

  Affiliation Division of Oxygen Biology, United Centers for Advanced Research and Translational Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan

  ⨯
• Masayuki Yamamoto ,

  Roles Resources

  ¶‡ TA, NS, MY, YO, GS and AN also contributed equally to this work.

  Affiliations Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan, Department of Biochemistry and Molecular Biology, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan

  ⨯
• Yuichi Ogino ,

  Roles Funding acquisition, Writing – review & editing

  ¶‡ TA, NS, MY, YO, GS and AN also contributed equally to this work.

  Affiliation Department of Anesthesiology, Kagawa University, Kagawa, Japan

  ⨯
• Gotaro Shirakami ,

  Roles Funding acquisition, Writing – review & editing

  ¶‡ TA, NS, MY, YO, GS and AN also contributed equally to this work.

  Affiliation Department of Anesthesiology, Kagawa University, Kagawa, Japan

  ⨯
• Akira Nishiyama

  Roles Funding acquisition, Resources

  ¶‡ TA, NS, MY, YO, GS and AN also contributed equally to this work.

  Affiliation Department of Pharmacology, Kagawa University, Kagawa, Japan

  ⨯