Increased secreted PLA2 in epithelial cells promotes the progression of chronic non-atrophic gastritis to chronic atrophic gastritis through the TGF-β signaling

Hairong Hao; Yanjun An; Yuan Liu; Baole Li; Ran Zhang; Yingli Hao; Yuanyuan Pan; Na Li; Junfeng Kang

doi:10.1371/journal.pone.0343531

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Open Access

Peer-reviewed

Research Article

Increased secreted PLA2 in epithelial cells promotes the progression of chronic non-atrophic gastritis to chronic atrophic gastritis through the TGF-β signaling

Hairong Hao ,

Contributed equally to this work with: Hairong Hao, Yanjun An

Roles Funding acquisition, Writing – original draft

Affiliations China Academy of Chinese Medical Sciences, Xiyuan Hospital, Shanxi Hospital, Taiyuan, Shanxi, China, Affiliated Hospital of Shanxi University of Traditional Chinese Medicine, Taiyuan, Shanxi, China, The First Clinical College of Shanxi University of Traditional Chinese Medicine, Taiyuan, Shanxi, China
⨯
Yanjun An ,

Contributed equally to this work with: Hairong Hao, Yanjun An

Roles Writing – original draft

Affiliations China Academy of Chinese Medical Sciences, Xiyuan Hospital, Shanxi Hospital, Taiyuan, Shanxi, China, Affiliated Hospital of Shanxi University of Traditional Chinese Medicine, Taiyuan, Shanxi, China, The First Clinical College of Shanxi University of Traditional Chinese Medicine, Taiyuan, Shanxi, China
⨯
Yuan Liu,

Roles Data curation, Resources

Affiliations China Academy of Chinese Medical Sciences, Xiyuan Hospital, Shanxi Hospital, Taiyuan, Shanxi, China, Affiliated Hospital of Shanxi University of Traditional Chinese Medicine, Taiyuan, Shanxi, China
⨯
Baole Li,

Roles Data curation, Investigation

Affiliations China Academy of Chinese Medical Sciences, Xiyuan Hospital, Shanxi Hospital, Taiyuan, Shanxi, China, Affiliated Hospital of Shanxi University of Traditional Chinese Medicine, Taiyuan, Shanxi, China
⨯
Ran Zhang,

Roles Methodology, Resources

Affiliations China Academy of Chinese Medical Sciences, Xiyuan Hospital, Shanxi Hospital, Taiyuan, Shanxi, China, Affiliated Hospital of Shanxi University of Traditional Chinese Medicine, Taiyuan, Shanxi, China
⨯
Yingli Hao,

Roles Data curation, Formal analysis

Affiliations China Academy of Chinese Medical Sciences, Xiyuan Hospital, Shanxi Hospital, Taiyuan, Shanxi, China, Affiliated Hospital of Shanxi University of Traditional Chinese Medicine, Taiyuan, Shanxi, China
⨯
Yuanyuan Pan,

Roles Formal analysis, Investigation

Affiliations China Academy of Chinese Medical Sciences, Xiyuan Hospital, Shanxi Hospital, Taiyuan, Shanxi, China, Affiliated Hospital of Shanxi University of Traditional Chinese Medicine, Taiyuan, Shanxi, China
⨯
Na Li ,

Roles Writing – review & editing

* E-mail: 280196833@qq.com (NL); kangjunfeng@sxtcm.edu.cn (JK)

Affiliations China Academy of Chinese Medical Sciences, Xiyuan Hospital, Shanxi Hospital, Taiyuan, Shanxi, China, Affiliated Hospital of Shanxi University of Traditional Chinese Medicine, Taiyuan, Shanxi, China, The First Clinical College of Shanxi University of Traditional Chinese Medicine, Taiyuan, Shanxi, China
⨯
Junfeng Kang

Roles Project administration, Writing – review & editing

* E-mail: 280196833@qq.com (NL); kangjunfeng@sxtcm.edu.cn (JK)

Affiliations China Academy of Chinese Medical Sciences, Xiyuan Hospital, Shanxi Hospital, Taiyuan, Shanxi, China, Affiliated Hospital of Shanxi University of Traditional Chinese Medicine, Taiyuan, Shanxi, China, The First Clinical College of Shanxi University of Traditional Chinese Medicine, Taiyuan, Shanxi, China

https://orcid.org/0009-0001-9486-4752

⨯

Increased secreted PLA2 in epithelial cells promotes the progression of chronic non-atrophic gastritis to chronic atrophic gastritis through the TGF-β signaling

Hairong Hao,
Yanjun An,
Yuan Liu,
Baole Li,
Ran Zhang,
Yingli Hao,
Yuanyuan Pan,
Na Li,
Junfeng Kang

Published: March 4, 2026
https://doi.org/10.1371/journal.pone.0343531

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Small interfering RNA
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Inflammation
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Epithelial cells
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Gastric mucosa
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Gastrointestinal tract
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RNA sequencing
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Gastritis
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Gene expression
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