Plasma heme pool compartmentalization is linked to pathophysiology in Sickle Cell Disease

• Moritz Saxenhofer ,

  Roles Conceptualization, Formal analysis, Visualization, Writing – original draft

  * E-mail: moritz.saxenhofer@cslbehring.com

  Affiliations CSL Behring, CSL Biologics Research Centre, Bern, Switzerland,, Swiss Institute for Translational and Entrepreneurial Medicine, sitem-insel, Bern, Switzerland

  https://orcid.org/0000-0002-5995-5026

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• Daniel Couto,

  Roles Methodology, Writing – review & editing

  Affiliations CSL Behring, CSL Biologics Research Centre, Bern, Switzerland,, Swiss Institute for Translational and Entrepreneurial Medicine, sitem-insel, Bern, Switzerland

  https://orcid.org/0000-0003-0223-1497

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• Sandra Mena Perez,

  Roles Investigation, Writing – review & editing

  Affiliations CSL Behring, CSL Biologics Research Centre, Bern, Switzerland,, Swiss Institute for Translational and Entrepreneurial Medicine, sitem-insel, Bern, Switzerland

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• Marlies Illi,

  Roles Investigation, Writing – review & editing

  Affiliations CSL Behring, CSL Biologics Research Centre, Bern, Switzerland,, Swiss Institute for Translational and Entrepreneurial Medicine, sitem-insel, Bern, Switzerland

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• Justine Brodard,

  Roles Investigation, Writing – review & editing

  Affiliation Department of Hematology and Central Hematology Laboratory, Inselspital, Bern University Hospital, Bern, Switzerland

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• Linet Njue,

  Roles Investigation, Writing – review & editing

  Affiliation Department of Hematology and Central Hematology Laboratory, Inselspital, Bern University Hospital, Bern, Switzerland

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• Ioannis Chanias,

  Roles Investigation, Writing – review & editing

  Affiliation Department of Hematology and Central Hematology Laboratory, Inselspital, Bern University Hospital, Bern, Switzerland

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• Cesare Medri,

  Roles Investigation, Writing – review & editing

  Current address: Department of Hematology, USB, Basel University Hospital, Switzerland

  Affiliation Department of Hematology and Central Hematology Laboratory, Inselspital, Bern University Hospital, Bern, Switzerland

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• Gerasimos Tsilimidos,

  Roles Investigation, Writing – review & editing

  Affiliation Service and Central Laboratory of Haematology, Department of Oncology and Department of Laboratory Medicines and Pathology, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland

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• Nicole Hadorn,

  Roles Investigation, Writing – review & editing

  Affiliation Department of Hematology and Central Hematology Laboratory, Inselspital, Bern University Hospital, Bern, Switzerland

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• Christelle Chirlias,

  Roles Investigation, Writing – review & editing

  Affiliation Service and Central Laboratory of Haematology, Department of Oncology and Department of Laboratory Medicines and Pathology, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland

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• Ana-Patricia Batista Mesquita,

  Roles Investigation, Writing – review & editing

  Affiliation Service and Central Laboratory of Haematology, Department of Oncology and Department of Laboratory Medicines and Pathology, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland

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• Lucas Veuthey,

  Roles Investigation, Writing – review & editing

  Affiliation Service and Central Laboratory of Haematology, Department of Oncology and Department of Laboratory Medicines and Pathology, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland

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• Anna Schnell,

  Roles Investigation, Writing – review & editing

  Affiliations CSL Behring, CSL Biologics Research Centre, Bern, Switzerland,, Swiss Institute for Translational and Entrepreneurial Medicine, sitem-insel, Bern, Switzerland

  https://orcid.org/0000-0003-0378-7809

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• Stefanie Graeter,

  Roles Methodology, Writing – review & editing

  Affiliations CSL Behring, CSL Biologics Research Centre, Bern, Switzerland,, Swiss Institute for Translational and Entrepreneurial Medicine, sitem-insel, Bern, Switzerland

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• Gregory J. Kato,

  Roles Investigation, Writing – review & editing

  Affiliation CSL Behring, Clinical Research & Development, King of Prussia, Pennsylvania, United States of America

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• Jacqueline Adam,

  Roles Investigation, Writing – review & editing

  Affiliations CSL Behring, CSL Biologics Research Centre, Bern, Switzerland,, Swiss Institute for Translational and Entrepreneurial Medicine, sitem-insel, Bern, Switzerland

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• Ramona Merki,

  Roles Investigation, Writing – review & editing

  Affiliation Oncology and Hematology Department, Aarau Cantonal Hospital, Aarau, Switzerland

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• Emmanuel Levrat,

  Roles Investigation, Writing – review & editing

  Affiliation Department of Hemato-Oncology, Hôpital Cantonal Fribourg, Fribourg, Switzerland

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• Kaveh Samii,

  Roles Investigation, Writing – review & editing

  Affiliation Clinical Hematology Unit, Geneva University Hospitals (HUG), Geneva, Switzerland

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• Mila Keiser,

  Roles Investigation, Writing – review & editing

  Affiliation Department of Hematology and Central Hematology Laboratory, Inselspital, Bern University Hospital, Bern, Switzerland

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• Kathrin Susann Bieri,

  Roles Project administration, Writing – review & editing

  Affiliation University of Bern, Department of Clinical Research, Bern, Switzerland

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• Alan G. Haynes,

  Roles Formal analysis, Writing – review & editing

  Affiliation University of Bern, Department of Clinical Research, Bern, Switzerland

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• Anne Angelillo-Scherrer,

  Roles Supervision, Writing – review & editing

  Affiliation Department of Hematology and Central Hematology Laboratory, Inselspital, Bern University Hospital, Bern, Switzerland

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• Lorenzo Alberio,

  Roles Supervision, Writing – review & editing

  Affiliation Service and Central Laboratory of Haematology, Department of Oncology and Department of Laboratory Medicines and Pathology, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland

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• Francesco Grandoni,

  Roles Supervision, Writing – review & editing

  Affiliation Service and Central Laboratory of Haematology, Department of Oncology and Department of Laboratory Medicines and Pathology, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland

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• Mathilde Gavillet ,

  Contributed equally to this work with: Mathilde Gavillet, Thomas Gentinetta, Alicia Rovó, Alexander Schaub

  Roles Conceptualization, Investigation, Writing – review & editing

  Affiliation Service and Central Laboratory of Haematology, Department of Oncology and Department of Laboratory Medicines and Pathology, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland

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• Thomas Gentinetta ,

  Contributed equally to this work with: Mathilde Gavillet, Thomas Gentinetta, Alicia Rovó, Alexander Schaub

  Roles Conceptualization, Methodology, Writing – review & editing

  Affiliations CSL Behring, CSL Biologics Research Centre, Bern, Switzerland,, Swiss Institute for Translational and Entrepreneurial Medicine, sitem-insel, Bern, Switzerland

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• Alicia Rovó ,

  Contributed equally to this work with: Mathilde Gavillet, Thomas Gentinetta, Alicia Rovó, Alexander Schaub

  Roles Conceptualization, Investigation, Supervision, Writing – review & editing

  Affiliation Department of Hematology and Central Hematology Laboratory, Inselspital, Bern University Hospital, Bern, Switzerland

  https://orcid.org/0000-0002-7757-4753

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•  [ ... ],
• Alexander Schaub

  Contributed equally to this work with: Mathilde Gavillet, Thomas Gentinetta, Alicia Rovó, Alexander Schaub

  Roles Conceptualization, Supervision, Writing – review & editing

  Affiliations CSL Behring, CSL Biologics Research Centre, Bern, Switzerland,, Swiss Institute for Translational and Entrepreneurial Medicine, sitem-insel, Bern, Switzerland

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