The neuroactive potential of the elderly human gut microbiome is associated with mental health status

• Paulina Calderón-Romero ,

  Contributed equally to this work with: Paulina Calderón-Romero, Benjamin Valderrama

  Roles Data curation, Formal analysis, Writing – original draft, Writing – review & editing

  Affiliations Center for Aging Research and Healthy Longevity, Faculty of Sciences, Universidad Mayor, Santiago, Chile, Fondap Geroscience Centre for Brain Health and Metabolism, Santiago, Chile

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• Benjamin Valderrama ,

  Contributed equally to this work with: Paulina Calderón-Romero, Benjamin Valderrama

  Roles Data curation, Formal analysis, Methodology, Writing – original draft, Writing – review & editing

  Affiliations Fondap Geroscience Centre for Brain Health and Metabolism, Santiago, Chile, APC Microbiome Ireland, University College Cork, Cork, Ireland,, Department of Anatomy and Neuroscience, University College Cork, Cork, Ireland

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• Thomaz F. S. Bastiaanssen,

  Roles Writing – original draft, Writing – review & editing

  Affiliations APC Microbiome Ireland, University College Cork, Cork, Ireland,, Department of Anatomy and Neuroscience, University College Cork, Cork, Ireland, Department of Psychiatry, Amsterdam University Medical Centers Location Vrije Universiteit Amsterdam, The Netherlands

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• Patricia Lillo,

  Roles Writing – review & editing

  Affiliations Fondap Geroscience Centre for Brain Health and Metabolism, Santiago, Chile, Department of Neuroscience and South Neurologic Department, Faculty of Medicine, University of Chile, Santiago, Chile

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• Daniela Thumala-Dockendorff,

  Roles Writing – review & editing

  Affiliations Fondap Geroscience Centre for Brain Health and Metabolism, Santiago, Chile, Psychology Department, Faculty of Social Sciences, Universidad de Chile, Santiago, Chile

  https://orcid.org/0000-0003-0392-7031

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• Gerard Clarke,

  Roles Writing – review & editing

  Affiliations APC Microbiome Ireland, University College Cork, Cork, Ireland,, Department of Psychiatry and Neurobehavioural Science, University College Cork, Cork, Ireland

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• John F. Cryan,

  Roles Writing – review & editing

  Affiliations APC Microbiome Ireland, University College Cork, Cork, Ireland,, Department of Anatomy and Neuroscience, University College Cork, Cork, Ireland

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• Andrea Slachevsky,

  Roles Conceptualization, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Writing – review & editing

  Affiliations Fondap Geroscience Centre for Brain Health and Metabolism, Santiago, Chile, Neuropsychology and Clinical Neuroscience Laboratory (LANNEC), Interdisciplinary Nucleus for Physiology, Biophysics and Pathophysiology– Institute of Biomedical Science, Neuroscience and East Neuroscience Departments, Faculty of Medicine, University of Chile, Santiago, Chile, Neurology and Psychiatry Department, Clínica Alemana-University Desarrollo, Santiago, Chile, Memory and Neuropsychiatric Center (CMYN), Memory Unit - Neurology Department, Hospital del Salvador and Faculty of Medicine, University of Chile, Santiago, Chile

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• Christian González-Billault ,

  Roles Conceptualization, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Writing – review & editing

  ^* chrgonza@uchile.cl (CG-B); felipe.court@umayor.cl (FAC)

  Affiliations Fondap Geroscience Centre for Brain Health and Metabolism, Santiago, Chile, Department of Biology, Faculty of Sciences, Universidad de Chile, Santiago, Chile, Department of Neurosciences, Faculty of Medicine, Universidad de Chile, Santiago, Chile, Public Nutrition Unit, Institute for Nutrition and Food Technology, Universidad de Chile, Santiago, Chile, Buck Institute for Research on Aging, Novato, California, United States of America

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• Felipe A. Court

  Roles Conceptualization, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Writing – review & editing

  ^* chrgonza@uchile.cl (CG-B); felipe.court@umayor.cl (FAC)

  Affiliations Center for Aging Research and Healthy Longevity, Faculty of Sciences, Universidad Mayor, Santiago, Chile, Fondap Geroscience Centre for Brain Health and Metabolism, Santiago, Chile, Buck Institute for Research on Aging, Novato, California, United States of America, Centro Científico y Tecnológico de Excelencia Ciencia & Vida, Fundación Ciencia & Vida, Santiago, Chile

  https://orcid.org/0000-0002-9394-7601

  ⨯