Extended thromboprophylaxis after hip fracture surgery: Real-world evidence of direct oral anticoagulants versus low molecular weight heparin of unfractionated heparin

María Manuela Clavijo; Juan Ignacio Ruiz; Martina Rodriguez Brindicci; Paula Rodriguez; Victoria Wauters; María de los Angeles Vicente Reparaz; Alex Mountford; Micaela Monteagudo; Manuela Camarero; Claudia Erica Casali; Carolina Mahuad; Florencia Aizpurua; Marta Elisa Zerga; Adriana Ventura; Nicolas Siciliano; Gonzalo Garate

doi:10.1371/journal.pone.0343020

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Peer-reviewed

Research Article

Extended thromboprophylaxis after hip fracture surgery: Real-world evidence of direct oral anticoagulants versus low molecular weight heparin of unfractionated heparin

María Manuela Clavijo ,

Contributed equally to this work with: María Manuela Clavijo, Juan Ignacio Ruiz, María de los Angeles Vicente Reparaz, Claudia Erica Casali, Carolina Mahuad, Florencia Aizpurua, Marta Elisa Zerga, Adriana Ventura, Nicolas Siciliano, Gonzalo Garate

Roles Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: mclavijo@hospitalaleman.com

Affiliation Department of Hematology, Hospital Alemán, Ciudad Autónoma de Buenos Aires, Argentina

https://orcid.org/0000-0002-6160-9915

⨯
Juan Ignacio Ruiz ,

Contributed equally to this work with: María Manuela Clavijo, Juan Ignacio Ruiz, María de los Angeles Vicente Reparaz, Claudia Erica Casali, Carolina Mahuad, Florencia Aizpurua, Marta Elisa Zerga, Adriana Ventura, Nicolas Siciliano, Gonzalo Garate

Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – review & editing

Affiliation Department of Clinical Medicine, Hospital Alemán, Ciudad Autónoma de Buenos Aires, Argentina
⨯
Martina Rodriguez Brindicci ,

Roles Data curation, Validation, Visualization, Writing – review & editing

¶‡ These authors also contributed equally to this work.

Affiliation Department of Hematology, Hospital Alemán, Ciudad Autónoma de Buenos Aires, Argentina
⨯
Paula Rodriguez ,

Roles Data curation, Validation, Visualization, Writing – review & editing

¶‡ These authors also contributed equally to this work.

Affiliation Department of Hematology, Hospital Alemán, Ciudad Autónoma de Buenos Aires, Argentina
⨯
Victoria Wauters ,

Roles Data curation, Validation, Visualization, Writing – review & editing

¶‡ These authors also contributed equally to this work.

Affiliation Department of Hematology, Hospital Alemán, Ciudad Autónoma de Buenos Aires, Argentina
⨯
María de los Angeles Vicente Reparaz ,

Contributed equally to this work with: María Manuela Clavijo, Juan Ignacio Ruiz, María de los Angeles Vicente Reparaz, Claudia Erica Casali, Carolina Mahuad, Florencia Aizpurua, Marta Elisa Zerga, Adriana Ventura, Nicolas Siciliano, Gonzalo Garate

Roles Conceptualization, Data curation, Supervision, Validation, Writing – review & editing

Affiliation Department of Hematology, Hospital Alemán, Ciudad Autónoma de Buenos Aires, Argentina
⨯
Alex Mountford ,

Roles Data curation, Validation, Visualization

¶‡ These authors also contributed equally to this work.

Affiliation Department of Clinical Medicine, Hospital Alemán, Ciudad Autónoma de Buenos Aires, Argentina
⨯
Micaela Monteagudo ,

Roles Data curation, Validation, Visualization

¶‡ These authors also contributed equally to this work.

Affiliation Department of Clinical Medicine, Hospital Alemán, Ciudad Autónoma de Buenos Aires, Argentina
⨯
Manuela Camarero ,

Roles Data curation, Validation, Visualization

¶‡ These authors also contributed equally to this work.

Affiliation Department of Clinical Medicine, Hospital Alemán, Ciudad Autónoma de Buenos Aires, Argentina
⨯
Claudia Erica Casali ,

Contributed equally to this work with: María Manuela Clavijo, Juan Ignacio Ruiz, María de los Angeles Vicente Reparaz, Claudia Erica Casali, Carolina Mahuad, Florencia Aizpurua, Marta Elisa Zerga, Adriana Ventura, Nicolas Siciliano, Gonzalo Garate

Roles Conceptualization, Investigation, Supervision, Validation, Visualization

Affiliation Department of Hematology, Hospital Alemán, Ciudad Autónoma de Buenos Aires, Argentina
⨯
Carolina Mahuad ,

Contributed equally to this work with: María Manuela Clavijo, Juan Ignacio Ruiz, María de los Angeles Vicente Reparaz, Claudia Erica Casali, Carolina Mahuad, Florencia Aizpurua, Marta Elisa Zerga, Adriana Ventura, Nicolas Siciliano, Gonzalo Garate

Roles Validation, Visualization, Writing – review & editing

Affiliation Department of Hematology, Hospital Alemán, Ciudad Autónoma de Buenos Aires, Argentina
⨯
Florencia Aizpurua ,

Contributed equally to this work with: María Manuela Clavijo, Juan Ignacio Ruiz, María de los Angeles Vicente Reparaz, Claudia Erica Casali, Carolina Mahuad, Florencia Aizpurua, Marta Elisa Zerga, Adriana Ventura, Nicolas Siciliano, Gonzalo Garate

Roles Investigation, Validation, Visualization

Affiliation Department of Hematology, Hospital Alemán, Ciudad Autónoma de Buenos Aires, Argentina
⨯
Marta Elisa Zerga ,

Contributed equally to this work with: María Manuela Clavijo, Juan Ignacio Ruiz, María de los Angeles Vicente Reparaz, Claudia Erica Casali, Carolina Mahuad, Florencia Aizpurua, Marta Elisa Zerga, Adriana Ventura, Nicolas Siciliano, Gonzalo Garate

Roles Validation, Visualization

Affiliation Department of Hematology, Hospital Alemán, Ciudad Autónoma de Buenos Aires, Argentina
⨯
Adriana Ventura ,

Contributed equally to this work with: María Manuela Clavijo, Juan Ignacio Ruiz, María de los Angeles Vicente Reparaz, Claudia Erica Casali, Carolina Mahuad, Florencia Aizpurua, Marta Elisa Zerga, Adriana Ventura, Nicolas Siciliano, Gonzalo Garate

Roles Validation, Visualization

Affiliation Department of Hematology, Hospital Alemán, Ciudad Autónoma de Buenos Aires, Argentina
⨯
Nicolas Siciliano ,

Contributed equally to this work with: María Manuela Clavijo, Juan Ignacio Ruiz, María de los Angeles Vicente Reparaz, Claudia Erica Casali, Carolina Mahuad, Florencia Aizpurua, Marta Elisa Zerga, Adriana Ventura, Nicolas Siciliano, Gonzalo Garate

Roles Validation, Visualization

Affiliation Department of Hematology, Hospital Alemán, Ciudad Autónoma de Buenos Aires, Argentina
⨯
[ ... ],
Gonzalo Garate

Contributed equally to this work with: María Manuela Clavijo, Juan Ignacio Ruiz, María de los Angeles Vicente Reparaz, Claudia Erica Casali, Carolina Mahuad, Florencia Aizpurua, Marta Elisa Zerga, Adriana Ventura, Nicolas Siciliano, Gonzalo Garate

Roles Conceptualization, Funding acquisition, Supervision, Validation, Visualization

Affiliation Department of Hematology, Hospital Alemán, Ciudad Autónoma de Buenos Aires, Argentina
⨯
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Extended thromboprophylaxis after hip fracture surgery: Real-world evidence of direct oral anticoagulants versus low molecular weight heparin of unfractionated heparin

María Manuela Clavijo,
Juan Ignacio Ruiz,
Martina Rodriguez Brindicci,
Paula Rodriguez,
Victoria Wauters,
María de los Angeles Vicente Reparaz,
Alex Mountford,
Micaela Monteagudo,
Manuela Camarero,
Claudia Erica Casali

Published: March 12, 2026
https://doi.org/10.1371/journal.pone.0343020

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