Network pharmacology and integrative bioinformatics analyses identify PDE1A as a key target of pirfenidone in idiopathic pulmonary fibrosis

Jing Wu; Haseeb Khaliq; Yanyan Ke; Qudrat Ullah; Sheikh Arslan Sehgal; Xue Yi

doi:10.1371/journal.pone.0342991

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Open Access

Peer-reviewed

Research Article

Network pharmacology and integrative bioinformatics analyses identify PDE1A as a key target of pirfenidone in idiopathic pulmonary fibrosis

Jing Wu,

Roles Conceptualization, Investigation, Methodology

Affiliations Key Laboratory of Functional and Clinical Translational Medicine, Fujian Provincial Department of Education, Xiamen Medical College, Xiamen, China, Shenzhen Center for Disease control and prevention, Shenzhen, Guangzhou, China
⨯
Haseeb Khaliq,

Roles Data curation, Project administration, Writing – review & editing

Affiliation Department of Anatomy and Histology, Cholistan University of Veterinary and Animal Sciences, Bahawalpur, Pakistan
⨯
Yanyan Ke ,

Roles Resources, Validation, Visualization, Writing – original draft

* E-mail: gillke@163.com (YK); qudratullah1@cuvas.edu.pk (QU); yxue@xmmc.edu.cn (XY)

Affiliations Key Laboratory of Functional and Clinical Translational Medicine, Fujian Provincial Department of Education, Xiamen Medical College, Xiamen, China, Institute of Respiratory Research, Xiamen Medical College, Xiamen, Fujian, China
⨯
Qudrat Ullah ,

Roles Writing – review & editing

* E-mail: gillke@163.com (YK); qudratullah1@cuvas.edu.pk (QU); yxue@xmmc.edu.cn (XY)

Affiliation Department of Theriogenology, Cholistan University of Veterinary and Animal Sciences, Bahawalpur, Pakistan

https://orcid.org/0009-0003-1171-6805

⨯
Sheikh Arslan Sehgal,

Roles Data curation, Software

Affiliation Department of Genomics and Bioinformatics, Cholistan University of Veterinary and Animal Sciences, Bahawalpur, Pakistan
⨯
Xue Yi

Roles Conceptualization, Funding acquisition, Project administration, Writing – original draft

* E-mail: gillke@163.com (YK); qudratullah1@cuvas.edu.pk (QU); yxue@xmmc.edu.cn (XY)

Affiliations Key Laboratory of Functional and Clinical Translational Medicine, Fujian Provincial Department of Education, Xiamen Medical College, Xiamen, China, Institute of Respiratory Research, Xiamen Medical College, Xiamen, Fujian, China
⨯

Network pharmacology and integrative bioinformatics analyses identify PDE1A as a key target of pirfenidone in idiopathic pulmonary fibrosis

Jing Wu,
Haseeb Khaliq,
Yanyan Ke,
Qudrat Ullah,
Sheikh Arslan Sehgal,
Xue Yi

Published: April 10, 2026
https://doi.org/10.1371/journal.pone.0342991

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